Age-associated, oxidatively modified proteins: A critical evaluation

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

[49] Determination of carbonyl content in oxidatively modified proteins

1990 • 5,654 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Protein Oxidation and Aging

1992 • 2,687 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

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1994 • 2,372 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

1987 • 840 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Conversion of Amino Acid Residues in Proteins and Amino Acid Homopolymers to Carbonyl Derivatives by Metal-catalyzed Oxidation Reactions

1989 • 488 citations

Differential susceptibility of plasma proteins to oxidative modification: Examination by western blot immunoassay

1994 • 464 citations

Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

1995 • 412 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Protein oxidative damage is associated with life expectancy of houseflies.

1993 • 347 citations

Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome

1996 • 333 citations

Methods for determination of aldehydic lipid peroxidation products

1989 • 330 citations

Fenton chemistry. Amino acid oxidation.

1991 • 290 citations

Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage

1995 • 288 citations

Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.

1983 • 266 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.

1985 • 244 citations

Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation

1993 • 222 citations

Cloning the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.

1996 • 219 citations

Age-Related Decline of Rat Liver Multicatalytic Proteinase Activity and Protection from Oxidative Inactivation by Heat-Shock Protein 90

1996 • 214 citations

Covalent modification reactions are marking steps in protein turnover

1990 • 211 citations

Protein-bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins

1993 • 191 citations

Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction

1992 • 190 citations

Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging

1996 • 184 citations

Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells

1989 • 182 citations

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

Sequence of a peptide susceptible to mixed-function oxidation. Probable cation binding site in glutamine synthetase.

1986 • 163 citations

Analysis of Protein Carbonyls with 2,4-Dinitrophenyl Hydrazine and Its Antibodies by Immunoblot in Two-Dimensional Gel Electrophoresis

1996 • 160 citations

Protein Modification in Aging

1988 • 160 citations

Brain synaptosomal aging: Free radicals and membrane fluidity

1995 • 147 citations

Carbonic Anhydrase III. OXIDATIVE MODIFICATION IN VIVO AND LOSS OF PHOSPHATASE ACTIVITY DURING AGING

1995 • 145 citations

Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens

1993 • 140 citations

Studies on lipid peroxidation and protein oxidation in the aging brain

1995 • 140 citations

Protein Oxidation and Aging 1. Difficulties in Measuring Reactive Protein Carbonyls in Tissues Using 2,4-Dinitrophenylhydrazine

1995 • 138 citations

Introduction of Carbonyl Groups into Proteins by the Lipid Peroxidation Product, Malondialdehyde

1996 • 136 citations

Ascorbic acid and oxidative inactivation of proteins

1991 • 127 citations

Protein modification in aging

1992 • 116 citations

Aging and Proteolysis of Oxidized Proteins

1994 • 116 citations

[25] Role of oxidized amino acids in protein breakdown and stability

1995 • 110 citations

Decreased protein and puromycinyl-peptide degradation in livers of senescent mice

1982 • 104 citations

Free radical theory of aging: History

1992 • 102 citations

High Altitude Training Increases Reactive Carbonyl Derivatives But Not Lipid Peroxidation in Skeletal Muscle of Rats

1997 • 89 citations

Role of oxygen in oxidation of lipid and protein during ischemia/reperfusion in isolated perfused rat lung

1992 • 66 citations

Age‐dependent accumulation of phosphatidylcholine hydroperoxide in the brain and liver of the rat

1993 • 61 citations

Effect of the Spin-Trapping CompoundN-tert-Butyl-α-phenylnitrone on Protein Oxidation and Life Span

1995 • 55 citations

A Renal Carcinogen Ferric Nitrilotriacetate Mediates a Temporary Accumulation of Aldehyde-Modified Proteins Within Cytosolic Compartment of Rat-Kidney

1995 • 54 citations

Aging of the Liver: Proteolysis of Oxidatively Modified Glutamine Synthetase

1995 • 53 citations

Free Radicals in Aging

1993 • 50 citations

Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.

1994 • 50 citations

Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

1995 • 48 citations

Alteration of aminoacyl-tRNA synthetase with age: Heat-labilization of the enzyme by oxidative damage

1990 • 46 citations

Different selectivities of oxidants during oxidation of methionine residues in the α‐1‐proteinase inhibitor

1989 • 46 citations

Amino acid oxidation.

1989 • 37 citations

Role of Carbohydrates in Oxidative Modification of Fibrinogen and Other Plasma Proteins

1995 • 37 citations

The ATP-independent pathway in red blood cells that degrades oxidant-damaged hemoglobin

1992 • 35 citations

Protein Oxidation and Aging II. Difficulties in Measuring Alkaline Protease Activity in Tissues Using the Fluorescamine Procedure

1995 • 31 citations

Effect of Age and Food Restriction on Alkaline Protease Activity in Rat Liver

1996 • 27 citations

Diquat-dependent protein carbonyl formation

1995 • 25 citations

[2] Isolation of 2,4,5-trihydroxyphenylalanine quinone (topa quinone) from copper amine oxidases

1995 • 23 citations

Age-associated changes of oxidative modification and turnover of proteins

1995 • 23 citations

Exposure of Rat Muscle Phosphoglycerate Kinase to a Nonenzymatic MFO System Generates the Old Form of the Enzyme

1991 • 23 citations

Age-related effects in enzyme catalysis

1984 • 22 citations

Enzymes and Altered Proteins

1982 • 16 citations

Age-dependence of free radical-induced oxidative damage in ischemic-reperfused rat heart

1996 • 5 citations