Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

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1990 • 5,654 citations

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1983 • 3,028 citations

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

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1990 • 1,100 citations

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1986 • 968 citations

Metal-catalyzed oxidation of proteins. Physiological consequences

1991 • 877 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

The Dawn of Darwinian Medicine

1991 • 707 citations

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1985 • 587 citations

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1988 • 587 citations

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1990 • 498 citations

Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing

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Protein oxidation and proteolysis during aging and oxidative stress

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Minitab Student Handbook.

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1986 • 330 citations

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1987 • 280 citations

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1992 • 279 citations

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1976 • 261 citations

Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat

1989 • 251 citations

Action of food restriction in delaying the aging process.

1982 • 243 citations

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1985 • 212 citations

Diet, life-style, and mortality in China: a study of the characteristics of 65 Chinese counties

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Protection of DNA damage by dietary restriction

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Age-dependence of molecular and functional changes in biological membrane properties

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Anti-lipoperoxidation action of food restriction

1987 • 139 citations

Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse

1990 • 123 citations

Influence of dietary restriction and aging on natural killer cell activity in mice.

1983 • 115 citations

Effect of different levels of calorie restriction on azoxymethane-induced colon carcinogenesis in male F344 rats.

1990 • 91 citations

Dietary Protein, Life-span, and Biochemical Variables in Female Mice

1976 • 76 citations

Calorie Source, Calorie Restriction, Immunity and Aging of (NZB/NZW)F1 Mice

1984 • 67 citations

Differential effects of dietary caloric and protein restriction in the aging rat

1983 • 63 citations

Body Weight Increment and Length of Life: The Effect of Genetic Constitution and Dietary Protein

1978 • 61 citations

Dietary Protein, Life-span, and Physiological Variables in Female Mice

1976 • 49 citations

Some biochemical parameters of ageing in relation to dietary protein

1983 • 44 citations

Inhibition of aflatoxin B₁-induced gamma-glutamyltranspeptidase positive (GGT⁺) hepatic preneoplastic foci and tumors by low protein diets: evidence that altered GGT⁺ foci indicate neoplastic potential

1992 • 36 citations

Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging.

1988 • 36 citations

Risks of Premature Death and Cancer Predicted by Body Weight in Early Adult Life

1991 • 36 citations

Effect of Protein Nutrition on Growth and Life Span in the Rat

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The effect of low protein-high dextrin diet and subsequent food restriction upon life prolongation in Fischer 344 male rats

1988 • 26 citations

Cell differentiation and l-ornithine decarboxylase activity in the small intestine of rats fed low and high protein diets

1982 • 25 citations

High Protein Intake Promotes the Growth of Hepatic Preneoplastic Foci in Fischer #344 Rats: Evidence that Early Remodeled Foci Retain the Potential for Future Growth

1991 • 24 citations

Dietary Energy Restriction Decreases Ex Vivo Spleen Prostaglandin E2 Synthesis in Emory Mice

1990 • 23 citations

Metabolic Rate and Thyroid Status in Rats Fed Diets of Different Protein-Energy Value: The Importance of Free T3

1984 • 21 citations

Effect of Dietary Protein Restriction or Food Restriction on Oxygen Consumption and Mitochondrial Distribution in Cardiac and Red and White Skeletal Muscle of Rats

1977 • 19 citations

Effect of Level of Dietary Protein and Total or Partial Starvation on Catalase and Superoxide Dismutase Activity in Cardiac and Skeletal Muscles in Young Rats

1984 • 19 citations

Thermogenesis, low‐protein diets, and decreased development of AFB1‐induced preneoplastic foci in rat liver

1991 • 18 citations

Enhanced induction of gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats fed a low-protein diet.

1991 • 8 citations