Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA

1993 • 831 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Oxidative damage to DNA: do we have a reliable biomarker?

1996 • 612 citations

Wavelength dependence of oxidative DNA damage induced by UV and visible light

1997 • 601 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells.

1993 • 407 citations

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

1990 • 347 citations

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

1994 • 337 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells

1997 • 260 citations

Ap endonucleases and dna glycosylases that recognize oxidative dna damage

1988 • 254 citations

Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking.

1996 • 253 citations

Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.

1993 • 246 citations

Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques

1992 • 242 citations

Inactivation of OGG1 increases the incidence of G · C→T · A transversions in Saccharomyces cerevisiae : evidence for endogenous oxidative damage to DNA in eukaryotic cells

1997 • 217 citations

Determination of 8-Oxoguanine in DNA by Gas Chromatography-Mass Spectrometry and HPLC-Electrochemical Detection: Overestimation of the Background Level of the Oxidized Base by the Gas Chromatography-Mass Spectrometry Assay

1995 • 204 citations

Cigarette Smoking Induces Formation of 8-Hydroxydeoxyguanosine, One of the Oxidative Dna Damages in Human Peripheral Leukocytes

1990 • 182 citations

DNA damage induced by photosensitizers in cellular and cell-free systems

1993 • 167 citations

Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein

1997 • 153 citations

New trends in photobiology

1993 • 146 citations

Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells

1989 • 141 citations

Structure and synthesis of a lipid-containing bacteriophage

1972 • 137 citations

[12] Oxidative DNA damage: Endonuclease fingerprinting

1994 • 133 citations

Repair of intrinsic DNA lesions

1990 • 126 citations

Purification and characterization of normal and mutant forms of T4 endonuclease V.

1982 • 119 citations

DNA Base Damage in Chromatin of γ-Irradiated Cultured Human Cells

1992 • 105 citations

Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process

1995 • 101 citations

The influence of the wavelength of ultraviolet radiation on survival, mutation induction and DNA repair in irradiated chinese hamster cells

1980 • 100 citations

Effect of Physical Exercise on the Content of 8‐Hydroxydeoxyguanosine in Nuclear DNA Prepared from Human Lymphocytes

1993 • 99 citations

Recognition of oxidized abasic sites by repair endonucleases

1994 • 99 citations

Sensitive analysis of oxidative DNA damage in mammalian cells: use of the bacterial Fpg protein in combination with alkaline unwinding

1996 • 98 citations

Repair of Oxidative Damage to DNA: Enzymology and Biology

1994 • 96 citations

Visible light generates oxidative DNA base modifications in high excess of strand breaks in mammalian cells

1994 • 94 citations

Enzymatic recognition of DNA modifications induced by singlet oxygen and photosensitizers

1990 • 93 citations

Oxidative DNA Damage in Human Respiratory Tract Epithelial Cells. Time Course in Relation to DNA Strand Breakage

1996 • 86 citations

Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes

1994 • 84 citations

Oxidative Damage to DNA: Do We Have a Reliable Biomarker?

1996 • 76 citations

Oxidative DNA damage in human cells: the influence of antioxidants and DNA repair

1997 • 73 citations

Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions

1996 • 72 citations

Sensitive detection of 8-hydroxy-2′-deoxyguanosine in DNA by ³²P-postlabeling assay and the basal levels in rat tissues

1996 • 70 citations

8-Hydroxydeoxyguanosine in human leukocyte DNA and daily health practice factors: effects of individual alcohol sensitivity.

1996 • 66 citations

UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts

1997 • 59 citations

Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution

1982 • 55 citations

Quantification of oxidative DNA modifications in mitochondria

1993 • 51 citations

8-Hydroxydeoxyguanosine levels in DNA of human breast cancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method

1995 • 46 citations

Detection of single-strand breaks and formamidopyrimidine-DNA glycosylase-sensitive sites in DNA of cultured human fibroblasts

1995 • 43 citations

Evidence for sensitisation of DNA to oxidative damage during isolation

1996 • 42 citations

7, 8-Dihydro-8-oxo-2′-deoxyguanosine present in DNA is not simply an artefact of isolation

1994 • 41 citations

Induction of oxidative DNA damage by ferric iron in mammalian cells

1995 • 40 citations

A novel DNA N-glycosylase activity of E. coli T4 endonuclease V that excises 4,6-diamino-5-formamidopyrimidine from DNA, a UV-radiation- and hydroxyl radical-induced product of adenine

1996 • 39 citations

DNA base damage in lymphocytes of cancer patients undergoing radiation therapy

1996 • 34 citations

Endonuclease-sensitive DNA modifications induced by acetone and acetophenone as photosensitizers

1993 • 33 citations

Structure and synthesis of a lipid-containing bacteriophage

1971 • 25 citations

Sensitive nonradioactive detection of UV-induced cyclobutane pyrimidine dimers in intact mammalian cells

1995 • 15 citations

8-Hydroxydeoxyguanosine in Human Leukocyte DNA and Daily Health Practice Factors: Effects of Individual Alcohol Sensitivity

1996 • 8 citations

UV‐sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts

1997 • 7 citations

Deleted Work

1955 • 0 citations