Bile Salt Transporters: Molecular Characterization, Function, and Regulation

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

1996 • 2,293 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

2000 • 1,801 citations

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1999 • 1,708 citations

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Nuclear Hormone Receptors and Gene Expression

2001 • 1,538 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1999 • 1,527 citations

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1999 • 1,441 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Vitamin D Receptor As an Intestinal Bile Acid Sensor

2002 • 1,100 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

2001 • 753 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis

1998 • 728 citations

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

2001 • 722 citations

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

1998 • 718 citations

MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

1998 • 718 citations

Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels

1997 • 699 citations

Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

2001 • 683 citations

Molecular Pathogenesis of Cholestasis

1998 • 669 citations

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

1999 • 663 citations

Humanized xenobiotic response in mice expressing nuclear receptor SXR

2000 • 655 citations

The multidrug resistance protein family

1999 • 654 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

2002 • 639 citations

A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

1999 • 630 citations

Molecular Pathogenesis of Cholestasis

2004 • 622 citations

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

2000 • 611 citations

Polymorphisms in OATP-C

2001 • 605 citations

Mutations in ABCC6 cause pseudoxanthoma elasticum

2000 • 575 citations

Bile Salt Transporters

2002 • 568 citations

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

2002 • 568 citations

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

2000 • 565 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1

1999 • 546 citations

Expression cloning of a rat liver Na(+)-independent organic anion transporter.

1994 • 535 citations

Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide

2000 • 516 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

2001 • 507 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1997 • 502 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood

2001 • 496 citations

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

2001 • 490 citations

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

1991 • 479 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

Redundant Pathways for Negative Feedback Regulation of Bile Acid Production

2002 • 462 citations

Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors

2002 • 462 citations

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.

1994 • 444 citations

Molecular Physiology and Pathophysiology of Tight Junctions I. Tight junction structure and function: lessons from mutant animals and proteins

2000 • 439 citations

The Orphan Nuclear Receptor, shp, Mediates Bile Acid-Induced Inhibition of the Rat Bile Acid Transporter, ntcp

2001 • 434 citations

Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

1999 • 431 citations

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1995 • 419 citations

Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism

2001 • 411 citations

Mechanisms and regulation of bile secretion

1991 • 402 citations

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier.

2000 • 399 citations

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1997 • 396 citations

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.

1984 • 393 citations

Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter

2000 • 390 citations

Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450

2001 • 381 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Up-regulation of the multidrug resistance genes,Mrp1andMdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver

1998 • 361 citations

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).

1997 • 361 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases

2001 • 354 citations

Bile Acids: The Good, the Bad, and the Ugly

1999 • 354 citations

Hereditary Chronic Conjugated Hyperbilirubinemia in Mutant Rats Caused by Defective Hepatic Anion Transport

1985 • 352 citations

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

1997 • 352 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.

1994 • 346 citations

Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter.

1994 • 346 citations

Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

2002 • 346 citations

Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene

1999 • 343 citations

Molecular Characterization and Tissue Distribution of a New Organic Anion Transporter Subtype (oatp3) That Transports Thyroid Hormones and Taurocholate and Comparison with oatp2

1998 • 338 citations

ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)

2000 • 333 citations

The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors

2002 • 328 citations

Expression of members of the multidrug resistance protein family in human term placenta

2000 • 321 citations

Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway

2001 • 319 citations

Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis

2001 • 312 citations

Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter.

1995 • 305 citations

Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

2002 • 305 citations

Molecular aspects of hepatobiliary transport

1997 • 304 citations

The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

2000 • 303 citations

Ursodeoxycholic acid aggravates bile infarcts in bile duct–ligated and Mdr2 knockout mice via disruption of cholangioles

2002 • 300 citations

Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain

1999 • 300 citations

Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter

1998 • 294 citations

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

1997 • 294 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis

1996 • 291 citations

Cholestatic Potential of Troglitazone as a Possible Factor Contributing to Troglitazone-Induced Hepatotoxicity: In Vivo and in Vitro Interaction at the Canalicular Bile Salt Export Pump (Bsep) in the Rat

2001 • 291 citations

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

2000 • 288 citations

Hepatic Transport of Bile Salts

2000 • 286 citations

Cellular localization and up-regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

2001 • 285 citations

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver

2001 • 284 citations

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

2002 • 279 citations

Identification of Glutathione as a Driving Force and Leukotriene C4 as a Substrate for oatp1, the Hepatic Sinusoidal Organic Solute Transporter

1998 • 274 citations

Byler disease. Fatal familial intrahepatic cholestasis in an Amish kindred.

1969 • 269 citations

Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile

1999 • 266 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.

1998 • 262 citations

Tissue Distribution and Induction of Human Multidrug Resistant Protein 3

2002 • 262 citations

Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver

2001 • 262 citations

Secretion of organic anions in the formation of urine and bile.

1959 • 262 citations

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1998 • 259 citations

Expression of the MRP2 Gene-Encoded Conjugate Export Pump in Human Kidney Proximal Tubules and in Renal Cell Carcinoma

1999 • 257 citations

Characterization of inducible nature of MRP3 in rat liver

2000 • 255 citations

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.

2001 • 255 citations

Functional expression of the canalicular bile salt export pump of human liver

2002 • 253 citations

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

1996 • 251 citations

Expression of the bile salt export pump is maintained after chronic cholestasis in the rat

2000 • 251 citations

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

1997 • 250 citations

Byler Disease

1969 • 250 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C–dependent mechanisms in cholestatic rat liver

2001 • 246 citations

Hepatic Secretion of Conjugated Drugs and Endogenous Substances

2000 • 245 citations

Transport of amphipathic anions by human multidrug resistance protein 3.

2000 • 237 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Loss of ATP-dependent Transport Activity in Pseudoxanthoma Elasticum-associated Mutants of Human ABCC6 (MRP6)

2002 • 234 citations

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.

1995 • 230 citations

COMPARISON OF RIFAMPICIN WITH PHENOBARBITONE FOR TREATMENT OF PRURITUS IN BILIARY CIRRHOSIS

1989 • 229 citations

Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone

1999 • 227 citations

Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

2000 • 226 citations

The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver

2000 • 225 citations

In situ localization of the hepatocytic na+/taurocholate cotransporting polypeptide in rat liver

1994 • 221 citations

Identification of a Mutation in the Ileal Sodium-dependent Bile Acid Transporter Gene That Abolishes Transport Activity

1995 • 221 citations

Oatp2 Mediates Bidirectional Organic Solute Transport: A Role for Intracellular Glutathione

2000 • 219 citations

Transport Function and Hepatocellular Localization of mrp6 in Rat Liver

2000 • 218 citations

NF-κB activation in pancreas induces pancreatic and systemic inflammatory response

2002 • 216 citations

Orphan Nuclear Receptors: The Exotics of Xenobiotics

2001 • 216 citations

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)¹

1998 • 214 citations

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

2001 • 212 citations

The state of the STATs: recent developments in the study of signal transduction to the nucleus

1997 • 212 citations

Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats

2002 • 211 citations

PLASMA MEMBRANES OF THE RAT LIVER

1969 • 211 citations

Localization and function of the organic anion–transporting polypeptide Oatp2 in rat liver

1999 • 209 citations

Vectorial Transport by Double-Transfected Cells Expressing the Human Uptake Transporter SLC21A8 and the Apical Export Pump ABCC2

2001 • 204 citations

Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system.

1991 • 203 citations

Targeted Disruption of the Microsomal Epoxide Hydrolase Gene

1999 • 195 citations

Familial intrahepatic cholestasis 1: Studies of localization and function

2001 • 193 citations

New concepts of mechanisms of hepatocyte bile formation.

1980 • 188 citations

Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).

2000 • 188 citations

Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile

1995 • 186 citations

Interleukin-1β Suppresses Retinoid Transactivation of Two Hepatic Transporter Genes Involved in Bile Formation

2000 • 186 citations

Immunologic distribution of an organic anion transport protein in rat liver and kidney

1996 • 182 citations

Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity

2002 • 182 citations

Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis

2000 • 181 citations

Expression, transport properties, and chromosomal location of organic anion transporter subtype 3

2000 • 180 citations

Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3

2001 • 179 citations

Organic Anion Transporting Polypeptide Mediates Organic Anion/HCO3− Exchange

1997 • 179 citations

Transport of Bile Acids in Hepatic and Non-Hepatic Tissues

2001 • 178 citations

Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei

1997 • 177 citations

ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt.

1991 • 176 citations

Transporters on Demand

2001 • 175 citations

Nuclear receptor regulation of hepatic function

2002 • 169 citations

Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

1999 • 169 citations

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.

1985 • 168 citations

Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine

2002 • 167 citations

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor

2002 • 167 citations

Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

1994 • 165 citations

Characterization of an Organic Anion-Transporting Polypeptide (OATP-B) in Human Placenta

2002 • 165 citations

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

1997 • 165 citations

Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes

1997 • 165 citations

Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis.

1993 • 164 citations

Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia

2001 • 163 citations

Tauroursodesoxycholate-induced choleresis involves p38MAPK activation and translocation of the bile salt export pump in rats

2001 • 163 citations

Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1α

2001 • 163 citations

Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters

1996 • 162 citations

Multidrug Resistance and Cancer: The Role of the Human ABC Transporter ABCG2

2002 • 161 citations

Bile Acid Induction of Cytokine Expression by Macrophages Correlates with Repression of Hepatic Cholesterol 7α-Hydroxylase

2000 • 159 citations

Bile Salt Sulphates in Cholestasis

1974 • 158 citations

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

2001 • 157 citations

Regulation of cholangiocyte bicarbonate secretion

2001 • 156 citations

Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat

2001 • 155 citations

Bile acid profiles in urine of patients with liver diseases

1979 • 154 citations

6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

1999 • 148 citations

Molecular regulation of hepatocellular transport systems in cholestasis

1999 • 147 citations

Hepatobiliary transport

2000 • 146 citations

Functional heterogeneity of the intrahepatic biliary epithelium

2000 • 145 citations

ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles

1992 • 144 citations

Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver

2000 • 144 citations

Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein.

1998 • 144 citations

Impaired Protein Maturation of the Conjugate Export Pump Multidrug Resistance Protein 2 As A Consequence of A Deletion Mutation in Dubin–Johnson Syndrome

2000 • 143 citations

Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver

2000 • 141 citations

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1996 • 141 citations

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: A murine gallstone map

2001 • 140 citations

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

1997 • 140 citations

Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets

1998 • 139 citations

Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties

2000 • 137 citations

The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II

2002 • 137 citations

ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles*1, *2

1991 • 136 citations

Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol.

1994 • 135 citations

“Don't Know Much Bile-ology”

2000 • 132 citations

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

2002 • 132 citations

Multiple Factors Regulate the Rat Liver Basolateral Sodium-dependent Bile Acid Cotransporter Gene Promoter

1996 • 132 citations

FIC1 Disease: A Spectrum of Intrahepatic Cholestatic Disorders

2001 • 131 citations

The Role of Phosphoinositide 3-Kinase in Taurocholate-induced Trafficking of ATP-dependent Canalicular Transporters in Rat Liver

1998 • 131 citations

Colonic absorption of unconjugated bile acids

1979 • 131 citations

FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte

2001 • 127 citations

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

1997 • 126 citations

Up-regulation of transporters of the MRP family by drugs and toxins

2001 • 126 citations

The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II

2002 • 125 citations

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta

1998 • 125 citations

Molecular Alterations in Hepatocyte Transport Mechanisms in Acquired Cholestatic Liver Disorders

2000 • 125 citations

Molecular cloning and characterization of the murine bile salt export pump

2000 • 124 citations

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

2000 • 124 citations

Interleukin-1β-mediated Suppression of RXR:RAR Transactivation of the Ntcp Promoter Is JNK-dependent

2002 • 123 citations

Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.

2002 • 123 citations

Hepatocyte-specific expression of the humanMDR3P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent inMdr2 (?/?) mice

1998 • 123 citations

Regulation of Hepatic Transport Systems Involved in Bile Secretion During Liver Regeneration in Rats

1999 • 122 citations

Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes

2001 • 122 citations

Genetic defects in hepatobiliary transport

2002 • 122 citations

Trafficking of Canalicular ABC Transporters in Hepatocytes

2002 • 121 citations

Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes

1993 • 121 citations

The secretory function of the liver: new aspects of hepatobiliary transport

1998 • 121 citations

Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes

1996 • 120 citations

Changes in the localization of the rat canalicular conjugate export pump mrp2 in phalloidin-induced cholestasis

1999 • 118 citations

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1997 • 115 citations

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport

1982 • 115 citations

The role of phospholipids in bile formation: what can we learn from animals and human disease?

2000 • 115 citations

Enhanced Expression of the Human Multidrug Resistance Protein 3 by Bile Salt in Human Enterocytes

2001 • 115 citations

Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.

1985 • 115 citations

Mechanisms of cholestasis.

1986 • 114 citations

Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions

2002 • 114 citations

Substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters

1999 • 114 citations

Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: A cohort analysis

1999 • 113 citations

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis

1997 • 112 citations

The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man

1997 • 111 citations

Protein Kinase C-Dependent Distribution of the Multidrug Resistance Protein 2 From the Canalicular to the Basolateral Membrane in Human Hepg2 Cells

2001 • 111 citations

Human Apical Sodium-dependent Bile Salt Transporter Gene (SLC10A2) Is Regulated by the Peroxisome Proliferator-activated Receptor α

2002 • 111 citations

The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

2001 • 109 citations

Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes

2001 • 107 citations

The role of the canalicular multispecific organic anion transporter in the disposal of endo-and xenobiotics

1994 • 106 citations

Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets

1995 • 105 citations

Elevated Levels of Hepatocyte Nuclear Factor 3β in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis

2000 • 105 citations

Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice

2002 • 104 citations

Characterization of the mouse bile salt export pump overexpressed in the baculovirus system

2001 • 102 citations

The molecular genetics of familial intrahepatic cholestasis

2000 • 102 citations

Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1

1999 • 102 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5.

1997 • 101 citations

Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles

1999 • 100 citations

Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia

1997 • 99 citations

Autoradiographic evidence for hepatic lobular concentration gradient of bile acid derivative

1980 • 99 citations

Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia

2001 • 99 citations

Expression of hepatic transporters OATP‐C and MRP2 in primary sclerosing cholangitis

2001 • 98 citations

Characterization of the 5′‐flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene

2000 • 96 citations

Introduction: Transport across the hepatocyte canalicular membrane

1997 • 96 citations

Regulation of cholangiocyte proliferation

2001 • 96 citations

Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver

1999 • 95 citations

Mechanisms for experimental buprenorphine hepatotoxicity: major role of mitochondrial dysfunction versus metabolic activation

2001 • 95 citations

Export pumps for anionic conjugates encoded by MRP genes

1999 • 95 citations

Sequence Analysis and Functional Characterization of the 5′-Flanking Region of the Rat Multidrug Resistance Protein 2 (MRP2) Gene

1998 • 92 citations

Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies

1994 • 92 citations

Transport of Drugs Across the Hepatic Sinusoidal Membrane: Sinusoidal Drug Influx and Efflux in the Liver

2000 • 92 citations

Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes.

1987 • 91 citations

Bile acid metabolism in early life: studies of amniotic fluid.

1990 • 91 citations

A missense mutation in FIC1 is associated with greenland familial cholestasis

2000 • 90 citations

Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system.

1986 • 90 citations

Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)

1999 • 88 citations

Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver

1990 • 88 citations

Intracellular Trafficking and Regulation of Canalicular ATP-Binding Cassette Transporters

2000 • 88 citations

Unexpected Clinical Remission of Cholestasis After Rifampicin Therapy in Patients With Normal or Slightly Increased Levels of Γ-Glutamyl Transpeptidase

1998 • 87 citations

Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells

1998 • 87 citations

Organ-specific alterations in RARα:RXRα abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis

2002 • 87 citations

Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP.

1993 • 85 citations

Short-Term Regulation of Canalicular Transport

2000 • 84 citations

Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp

1999 • 84 citations

Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane

1999 • 83 citations

A Yeast ATP-binding Cassette-type Protein Mediating ATP-dependent Bile Acid Transport

1997 • 83 citations

Phylogenic and ontogenic expression of hepatocellular bile acid transport.

1993 • 83 citations

Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum

1996 • 82 citations

The Functional Expression of Sodium-dependent Bile Acid Transport in Madin-Darby Canine Kidney Cells Transfected with the cDNA for Microsomal Epoxide Hydrolase

1996 • 81 citations

Regulation and translocation of ATP-dependent apical membrane proteins in rat liver

1997 • 81 citations

Genes and cholestasis

2001 • 81 citations

Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green.

2001 • 80 citations

Sodium-coupled Taurocholate Transport in the Proximal Convolution of the Rat Kidney In Vivo and In Vitro

1981 • 80 citations

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with anmdr1agene disruption

1998 • 78 citations

Intracellular transport of bile acids

2000 • 77 citations

Regulation of organic anion and drug transporters of the sinusoidal membrane

1999 • 76 citations

Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene

1997 • 76 citations

On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α

2002 • 76 citations

Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice

2002 • 76 citations

Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients

1985 • 75 citations

Altered bile acid metabolism in primary biliary cirrhosis

1981 • 75 citations

Bile duct epithelium: frontiers in transport physiology

1996 • 74 citations

Retrieval of the mrp2 Gene Encoded Conjugate Export Pump from the Canalicular Membrane Contributes to Cholestasis Induced by tert-Butyl Hydroperoxide and Chloro-Dinitrobenzene

2000 • 74 citations

Effect of albumin binding on the hepatic transport of rose bengal: surface-mediated dissociation of limited capacity.

1982 • 74 citations

cAMP increases liver Na⁺-taurocholate cotransport by translocating transporter to plasma membranes

1997 • 74 citations

Stimulation of bile acid 6α-hydroxylation by rifampin

1996 • 74 citations

Bile acid transporters

1995 • 73 citations

Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse.

1998 • 73 citations

Bile acid transport and regulating functions in the human biliary epithelium

2001 • 72 citations

Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter

1998 • 72 citations

Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication

1993 • 71 citations

Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X

1999 • 71 citations

Down-regulation by Extracellular ATP of Rat Hepatocyte Organic Anion Transport Is Mediated by Serine Phosphorylation of Oatp1

2000 • 70 citations

Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes

1999 • 69 citations

Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8

2002 • 68 citations

Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids

1996 • 68 citations

Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles.

1986 • 67 citations

Induction of Mdr1b expression by tumor necrosis factor-α in rat liver cells is independent of p53 but requires NF-κB signaling

2001 • 67 citations

Hepatobiliary Transport: Molecular Mechanisms of Development and Cholestasis

1998 • 67 citations

Asynchronous expression and colocalization of Bsep and Mrp2 during development of rat liver

2002 • 66 citations

Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi

2001 • 66 citations

Mechanisms of Biliary Lipid Secretion and Their Role in Lipid Homeostasis

2000 • 65 citations

Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport

2000 • 65 citations

Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations

2001 • 65 citations

Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4α in rat liver

2001 • 64 citations

DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver

1990 • 64 citations

Sodium cotransport proteins

1992 • 64 citations

The Role of the Sinusoidal Endothelium in Liver Function

1999 • 64 citations

Multiple Canalicular Transport Mechanisms for Glutathione S-Conjugates

1995 • 63 citations

Regulation of cholangiocyte bile secretion

1999 • 62 citations

Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways

2002 • 60 citations

Characterization, cDNA Cloning, and Functional Expression of Mouse Heal Sodium-Dependent Bile Acid Transporter

1999 • 60 citations

The cytoskeleton of the hepatocyte

1989 • 59 citations

Expression of the rat liver Na+/taurocholate cotransporter is regulatedin vivo by retention of biliary constituents but not their depletion

1997 • 58 citations

Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver

2001 • 58 citations

Fetal and Neonatal Expression of the Apical Sodium-Dependent Bile Acid Transporter in the Rat Ileum and Kidney1

1997 • 57 citations

Transcriptional Control of Hepatocanalicular Transporter Gene Expression

2000 • 57 citations

Influence of bile acids on bile canalicular membrane morphology and the lobular gradient in canalicular size.

1978 • 57 citations

Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver.

2001 • 56 citations

Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations.

1993 • 56 citations

Membrane Topology and Cell Surface Targeting of Microsomal Epoxide Hydrolase

1999 • 56 citations

Protein Kinase B/Akt Mediates cAMP- and Cell Swelling-stimulated Na+/Taurocholate Cotransport and Ntcp Translocation

2002 • 55 citations

Effect of maternal cholestasis on bile acid transfer across the rat placenta–maternal liver tandem

2000 • 55 citations

Functional analysis of the rat bile salt export pump gene promoter

2002 • 55 citations

Effect of Albumin Binding on Extraction of Sulfobromophthalein by Perfused Elasmobranch Liver: Evidence for Dissociation-Limited Uptake

1984 • 55 citations

Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver

2000 • 54 citations

Na(+)-dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase

1993 • 54 citations

Downregulation of ileal bile acid absorption in bile-duct-ligated rats

2000 • 53 citations

Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver

1999 • 53 citations

Molecular Mechanisms in Bile Formation

2000 • 52 citations

Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids

1991 • 52 citations

The Rat Liver Na+/Bile Acid Cotransporter

2001 • 51 citations

Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats

2002 • 51 citations

Molecular identification and functional characterization of Mdr1a in rat cholangiocytes

2000 • 49 citations

Ontogenic expression of the Na+-independent organic anion transporting polypeptide (oatp) in rat liver and kidney

1996 • 47 citations

Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate

2001 • 47 citations

Divergent homeobox geneHexregulates promoter of the Na⁺-dependent bile acid cotransporter

2000 • 46 citations

Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells

1997 • 45 citations

Biliary secretion in elasmobranchs. II. Hepatic uptake and biliary excretion of organic anions

1976 • 44 citations

The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate

2002 • 43 citations

Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver

1999 • 43 citations

Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport

2001 • 43 citations

Role of Protein Phosphatases in Cyclic AMP-mediated Stimulation of Hepatic Na+/Taurocholate Cotransport

1998 • 43 citations

Identification of the Bile Acid-binding Site of the Ileal Lipid-binding Protein by Photoaffinity Labeling, Matrix-assisted Laser Desorption Ionization-Mass Spectrometry, and NMR Structure

2001 • 42 citations

Membrane Insertion Scanning of the Human Ileal Sodium/Bile Acid Co-transporter

1999 • 41 citations

Topological Photoaffinity Labeling of the Rabbit Ileal Na⁺/Bile‐Salt‐Cotransport System

1997 • 41 citations

Cloning of the Full-Length Coding Sequence of Rat Liver-Specific Organic Anion Transporter-1 (rlst-1) and a Splice Variant and Partial Characterization of the Rat lst-1 Gene

2000 • 39 citations

Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization

1997 • 39 citations

Fluorescent derivatives of bile salts. I. Synthesis and properties of NBD-amino derivatives of bile salts.

1991 • 38 citations

Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes.

1992 • 37 citations

Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: Studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid

1997 • 37 citations

Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrationsrted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097.

1999 • 35 citations

Radiation-inactivation analysis of the Na+/bile acid co-transport system from rabbit ileum

1995 • 35 citations

Progressive Familial Intrahepatic Cholestasis with High γ-Glutamyltranspeptidase Levels in Taiwanese Infants: Role of MDR3 Gene Defect?

2001 • 34 citations

Effect of bile on the intestinal bile‐acid binding protein (I‐BABP) expression. In vitro and in vivo studies

1996 • 34 citations

Fluorescent derivatives of bile salts. II. Suitability of NBD-amino derivatives of bile salts for the study of biological transport.

1991 • 33 citations

Evidence for an anion exchange mechanism for uptake of conjugated bile acid from the rat jejunum

1999 • 32 citations

Structural and Functional Characterization of Liver Cell-Specific Activity of the Human Sodium/Taurocholate Cotransporter

2000 • 32 citations

An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins

2002 • 31 citations

Reconstitution and characterization of ATP-dependent bile acid transport in human and rat placenta

1995 • 30 citations

Isolation and characterization of a polarized isolated hepatocyte preparation in the skate Raja erinacea

1987 • 30 citations

Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump

2000 • 29 citations

Hormonal regulation of expression of ileal bile acid binding protein in suckling rats

2000 • 28 citations

Taurocholate uptake by isolated skate hepatocytes: effect of albumin

1987 • 28 citations

A bile alcohol sulfate as a major component in the bile of the small skate (Raja erinacea).

1989 • 26 citations

Semiquantitation of intrahepatic MDR3 mRNA levels by reverse transcription/competitive polymerase chain reaction

1997 • 24 citations

Enhancement of unbound clearance of ICG by plasma proteins, demonstrated in human subjects and interpreted without assumption of facilitating structures

1993 • 24 citations

Molecular cloning of the murine cMOAT ATPase

2000 • 23 citations

Cracking the genetic code for benign recurrent and progressive familial intrahepatic cholestasis

1998 • 23 citations

Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2

2002 • 22 citations

A sharper image of SHP

2002 • 21 citations

Foreword: from classic bile physiology to cloned transporters.

2000 • 20 citations

Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea)

1997 • 20 citations

Nontraditional effects of protein binding and hematocrit on uptake of indocyanine green by perfused rat liver

1997 • 18 citations

HNF-1 alpha: have bile acid transport genes found their “master”?

2002 • 16 citations

Cytoskeleton of the hepatocyte.

1979 • 15 citations

FIC1: another bile salt carrier within the enterohepatic circulation?

2001 • 12 citations

Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters

1996 • 12 citations

Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes

1995 • 12 citations

Transcriptional regulation of acute phase genes by IL-6 and related cytokines.

1994 • 12 citations

The gene encoding the multispecific organic anion transporter (Cmoat) of the hepatocyte canalicular membrane maps to mouse Chromosome 19

1998 • 11 citations

Advancing the bile-ology of cholestatic liver disease

2001 • 10 citations

Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea

1991 • 9 citations

Endotoxin increases paracellular permeability of isolated rat hepatocyte couplets

2001 • 8 citations

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2002 • 8 citations

Zonal changes of hepatobiliary taurocholate transport in intrahepatic cholestasis induced by 17α-ethinyl estradiol: A histoautoradiographic study in rats

1993 • 7 citations

Genetic analysis of progressive familial intrahepatic cholestasis

2001 • 4 citations

Alterations of hepatobiliary transporter expression in primary biliary cirrhosis (PBC)

2002 • 2 citations

Characterization of HCV RNA particles from the serum of a patient with common variable immunodeficiency on isotonic iodixanol (OPTIPREP) gradients. Association with apolipoprotein-B100

2002 • 1 citations

Glibenclamide induces ductal secretion stimulating vesicular transport in cholangiocytes

2002 • 1 citations