Regulation of cholangiocyte proliferation

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

1998 • 776 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Primary Sclerosing Cholangitis

1984 • 365 citations

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

1999 • 325 citations

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

1988 • 314 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat

1990 • 227 citations

Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver

1996 • 224 citations

Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver

1989 • 206 citations

Primary Sclerosing Cholangitis

1984 • 202 citations

Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis

1999 • 202 citations

Extended lamivudine retreatment for chronic hepatitis B: Maintenance of viral suppression after discontinuation of therapy

1999 • 198 citations

Ductular Reaction in the Livers

1995 • 183 citations

Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats

2000 • 176 citations

Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation

1998 • 174 citations

Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

1999 • 169 citations

Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes

1997 • 165 citations

Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct–ligated rats

1999 • 160 citations

Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism.

1992 • 151 citations

Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation

1997 • 148 citations

Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion

1997 • 144 citations

Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells: Implications for vaccine development

1999 • 143 citations

Isolation, Culture, and Transplantation of Intrahepatic Biliary Epithelial Cells and Oval Cells

1990 • 141 citations

Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation

1994 • 141 citations

Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion

1996 • 139 citations

Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver

1999 • 129 citations

Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes

1997 • 125 citations

The pathobiology of biliary epithelia

1997 • 121 citations

Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase

1999 • 119 citations

Bile secretory function of intrahepatic biliary epithelium in the rat

1989 • 110 citations

Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver

1999 • 110 citations

Isolation of small polarized bile duct units.

1995 • 107 citations

Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type i ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium

1998 • 102 citations

Gastrin inhibits cholangiocyte growth in bile duct–ligated rats by interaction with cholecystokinin-B/gastrin receptors viaD -myo-inositol 1,4,5-triphosphate–, Ca2+-, and protein kinase Cα–dependent mechanisms

2000 • 101 citations

Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: A morphological study

1996 • 97 citations

Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor ? in a bile duct ligated rat model of cirrhosis

1997 • 85 citations

Prostaglandin E2 and rat liver regeneration

1993 • 76 citations

Expression of ?-fetoprotein and stem cell factor/c-kit system in bile duct ligated young rats

1997 • 75 citations

Cell proliferation and oncogene expression after bile duct ligation in the rat: evidence of a specific growth effect on bile duct cells.

1995 • 65 citations

Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat

1992 • 64 citations

Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat.

1994 • 62 citations

Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice.

1997 • 62 citations

Transforming growth factor-β1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat

1994 • 55 citations

Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction.

1993 • 42 citations

6-hydroxydopamine lesion of rat nigrostriatal dopaminergic neurons differentially affects nicotinic acetylcholine receptor subunit mRNA expression

1998 • 35 citations

Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells

1995 • 13 citations

Laparoscopic minimal-access surgery: Where are we now? where are we going?

2000 • 11 citations

G Proteins in Rat Liver Proliferation During Cholestasis

1994 • 10 citations

Ursodeoxycholic acid feeding inhibits secretin-induced cholangiocyte secretory processes in bile duct ligated rats

1998 • 5 citations

Camp stimulates secretory and proliferative capacity of the rat intrahepatic biliary epithelium through the PKA system

2000 • 2 citations