MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Structure and Function of Intercellular Junctions

1974 • 1,339 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Tight junctions and the molecular basis for regulation of paracellular permeability

1995 • 825 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Occludin is a functional component of the tight junction

1996 • 632 citations

Barrier function of epithelia

1981 • 616 citations

Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula Occludens

1978 • 569 citations

The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

1993 • 567 citations

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

1997 • 527 citations

Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border

1985 • 525 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

Cingulin, a new peripheral component of tight junctions

1988 • 505 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

1994 • 490 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

1986 • 446 citations

Freeze-fracture replica electron microscopy combined with sds digestion for cytochemical labeling of integral membrane proteins: Application to the immunogold labeling of intercellular junctional complexes

1995 • 430 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.

1996 • 353 citations

Membrane asymmetry in epithelia: is the tight junction a barrier to diffusion in the plasma membrane?

1981 • 350 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium.

1990 • 325 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

Evidence that tyrosine phosphorylation may increase tight junction permeability

1995 • 318 citations

Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear.

1982 • 310 citations

Rho: theme and variations

1996 • 290 citations

Symplekin, a novel type of tight junction plaque protein.

1996 • 286 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

Loss of Occludin and Functional Tight Junctions, but Not ZO-1, during Neural Tube Closure—Remodeling of the Neuroepithelium Prior to Neurogenesis

1996 • 278 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction

1996 • 268 citations

Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2.

1993 • 266 citations

Essential Role fordlgin Synaptic Clustering of Shaker K⁺ChannelsIn Vivo

1997 • 262 citations

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1994 • 228 citations

The structure and regulation of tight junctions

1993 • 208 citations

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

1996 • 204 citations

Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures

1996 • 193 citations

Two classes of tight junctions are revealed by ZO-1 isoforms

1993 • 189 citations

Submembranous junctional plaque proteins include potential tumor suppressor molecules.

1993 • 179 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

Contraction of isolated brush borders from the intestinal epithelium.

1976 • 178 citations

Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo

1990 • 171 citations

Involvement of a Heterotrimeric G Protein α Subunit in Tight Junction Biogenesis

1996 • 136 citations

Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

1996 • 134 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

Effects of glutaraldehyde fixation on the structure of tight junctions. A quantitative freeze-fracture analysis

1979 • 107 citations

The Movement of Solutes and Cells across Tight Junctionsa

1992 • 106 citations

ZO-1 and cingulin: tight junction proteins with distinct identities and localizations

1989 • 105 citations

The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain

1996 • 102 citations

The Tight Junction Protein ZO-2 Contains Three PDZ (PSD-95Discs-LargeZO-1) Domains and an Alternatively Spliced Region

1996 • 99 citations

Rapid Massive Assembly of Tight Junction Strands

1981 • 96 citations

The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.

1996 • 74 citations

Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets

1991 • 73 citations

Epithelial differentiation in the mouse preimplantation embryo: making adhesive cell contacts for the first time

1995 • 72 citations

Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers

1993 • 46 citations

Sequential Decrease in Tight Junctions as Revealed by 7H6 Tight Junction‐associated Protein during Rat Hepatocarcinogenesis

1994 • 34 citations

Vasopressin and A23187 stimulate phosphorylation of myosin light chain-1 in isolated rat hepatocytes

1991 • 34 citations

Chapter 11 Protein Interactions in the Tight Junction: The Role of MAGUK Proteins in Regulating Tight Junction Organization and Function

1996 • 25 citations

Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets

1991 • 7 citations

Isolation of cDNA Encoding 7H6-Reactive Polypeptide Defines a New Class of Protein with alpha-Helical Coiled-Coil Structure and DA-Box Similar to Yeast Chromosomal Segregation Proteins

1995 • 4 citations