Mechanisms and regulation of bile secretion

Glutathione and Related γ-Glutamyl Compounds: Biosynthesis and Utilization

1976 • 846 citations

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

1989 • 596 citations

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.

1984 • 393 citations

Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation.

1987 • 383 citations

Intestinal absorptive cell tight junctions are linked to cytoskeleton

1987 • 343 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

1988 • 314 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction

1987 • 243 citations

Cloning and Expression of a cDNA Coding for a Rat Liver Plasma Membrane Ecto-ATPase

1989 • 240 citations

Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents

1986 • 237 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat

1990 • 227 citations

Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier.

1984 • 225 citations

Biochemistry of bile secretion

1987 • 221 citations

Evidence for a Vesicular Transport Mechanism in Hepatocytes for Biliary Secretion of Immunoglobulin A

1980 • 219 citations

Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.

1986 • 210 citations

Contractility of Bile Canaliculi: Implications for Liver Function

1981 • 189 citations

New concepts of mechanisms of hepatocyte bile formation.

1980 • 188 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

The transport of bile acids in liver cells

1988 • 182 citations

Activation of fast skeletal muscle: contributions of studies on skinned fibers

1981 • 180 citations

Bile Secretory Apparatus: Evidence for a Vesicular Transport Mechanism for Proteins in the Rat, Using Horseradish Peroxidase and [125I]Insulin

1980 • 172 citations

Effects of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes

1986 • 163 citations

Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte.

1978 • 154 citations

Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding.

1986 • 143 citations

Cellular mechanisms of bile formation

1982 • 140 citations

(Na + K + 2Cl) cotransport in cultured embryonic chick heart cells

1988 • 137 citations

Misoprostol provides a colonic mucosal protective effect during acetic acid-induced colitis in rats

1990 • 135 citations

Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane.

1985 • 134 citations

Transcellular transport of polymeric IgA in the rat hepatocyte: biochemical and morphological characterization of the transport pathway.

1985 • 134 citations

Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability.

1980 • 131 citations

Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.

1988 • 130 citations

Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells.

1988 • 127 citations

Plasma membrane protein sorting in epithelial cells: Do secretory pathways hold the key?

1988 • 121 citations

Taurocholate transport by rat liver canalicular membrane vesicles. Evidence for the presence of an Na+-independent transport system.

1984 • 119 citations

Effect of diabetes on Na(+)-H+ exchange by single isolated hepatocytes

1991 • 117 citations

Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.

1985 • 115 citations

Mechanisms of cholestasis.

1986 • 114 citations

Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion†

1989 • 112 citations

Intracellular pH regulation in isolated rat bile duct epithelial cells.

1991 • 110 citations

Stimulus-Secretion Coupling in the Gastrointestinal Tract

1976 • 110 citations

Hepatocyte plasma membrane ecto-ATPase (pp120HA4) is a substrate for tyrosine kinase activity of the insulin receptor

1990 • 108 citations

Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport.

1989 • 108 citations

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

1989 • 108 citations

Expression of the hepatocyte Na+/bile acid cotransporter in Xenopus laevis oocytes.

1990 • 106 citations

Hepatotoxic bile acids increase cytosolic Ca++ activity of isolated rat hepatocytes

1988 • 104 citations

Biliary secretion of fluid-phase markers by the isolated perfused rat liver. Role of transcellular vesicular transport.

1985 • 101 citations

Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor.

1987 • 100 citations

Multispecificity of Na+-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles.

1989 • 98 citations

Properties of (Na+ + K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi

1975 • 97 citations

Isolation and characterization of the putative canalicular bile salt transport system of rat liver.

1987 • 92 citations

The Role of Cytoplasmic Proteins in Hepatic Bile Acid Transport

1989 • 91 citations

Electrogenic Na+-ascorbate cotransport in cultured bovine pigmented ciliary epithelial cells

1989 • 91 citations

Agonist-induced isotonic contraction of cultured mesangial cells after multiple passage

1985 • 90 citations

Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver

1990 • 88 citations

Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver.

1987 • 88 citations

Tight Junctions in Normal and Cholestatic Liver: Does the Paracellular Pathway Have Functional Significance?

1983 • 86 citations

Biogenesis of Endogenous Plasma Membrane Proteins in Epithelial Cells

1989 • 84 citations

Two Ca2+-dependent ATPases in rat liver plasma membrane. The previously purified (Ca2+-Mg2+)-ATPase is not a Ca2+-pump but an ecto-ATPase.

1988 • 83 citations

Localization of the Ecto-ATPase (Ecto-nucleotidase) in the Rat Hepatocyte Plasma Membrane

1989 • 82 citations

Immunoperoxidase localization of bile salts in rat liver cells. Evidence for a role of the Golgi apparatus in bile salt transport.

1988 • 82 citations

Heat induces intracellular acidification in human A-431 cells: role of Na(+)-H+ exchange and metabolism

1990 • 75 citations

Rapid kinetic analysis of the bile-salt-dependent secretion of phospholipid, cholesterol and a plasma-membrane enzyme into bile

1984 • 74 citations

Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture

1988 • 74 citations

Rat hepatocytes exhibit basolateral Na+/HCO3- cotransport.

1989 • 72 citations

The sinusoidal domain of the plasma membrane of rat hepatocytes contains an amiloride-sensitive Na+/H+ antiport.

1984 • 72 citations

Functional reconstitution of the canalicular bile salt transport system of rat liver.

1988 • 69 citations

Effects of ion substitution on bile acid-dependent and -independent bile formation by rat liver.

1982 • 67 citations

Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles.

1986 • 67 citations

Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain.

1988 • 66 citations

Biochemical localization of hepatic surface-membrane Na+,K+-ATPase activity depends on membrane lipid fluidity.

1988 • 63 citations

Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver

1989 • 63 citations

Overview of Epithelial Polarity

1989 • 62 citations

Serial quantitative image analysis and confocal microscopy of hepatic uptake, intracellular distribution and biliary secretion of a fluorescent bile acid analog in rat hepatocyte doublets

1990 • 60 citations

The cytoskeleton of the hepatocyte

1989 • 59 citations

Properties of the canalicular bile acid transport system in rat liver

1987 • 59 citations

Characterization of the anion transport system in hepatocyte plasma membranes.

1980 • 59 citations

Translocation of fatty acids across the basolateral rat liver plasma membrane is driven by an active potential-sensitive sodium-dependent transport system.

1987 • 58 citations

Characteristics of bile acid-mediated Ca2+ release from permeabilized liver cells and liver microsomes

1989 • 57 citations

Effects of kinins on cultured arterial smooth muscle

1990 • 57 citations

The calcium ionophore A23187 increases the tight-junctional permeability in rat liver

1988 • 54 citations

Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry.

1989 • 54 citations

Taurocholate transport by basolateral plasma membrane vesicles isolated from human liver

1989 • 52 citations

Hepatic handling of bile salts and protein in the rat during intrahepatic cholestasis

1983 • 51 citations

Coordination of the contractile activity of bile canaliculi. Evidence from calcium microinjection of triplet hepatocytes.

1985 • 51 citations

Calcium channels in hepatocytes

1988 • 51 citations

Mechanisms of Bile Secretion and Hepatic Transport

1986 • 49 citations

Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver.

1990 • 47 citations

Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucuronidation

1988 • 47 citations

Two distinct mechanisms for taurocholate uptake in subcellular fractions from rat liver.

1984 • 46 citations

Tissue Distribution and Subcellular Localization of an Endogenous Substrate (ppl20) for the Insulin Receptor-Associated Tyrosine Kinase

1986 • 46 citations

The role of an albumin receptor in hepatic organic anion uptake: The controversy continues

1987 • 39 citations

Proteolytic processing of rat liver membrane secretory component. Cleavage activity is localized to bile canalicular membranes.

1988 • 38 citations

Role of Cytokeratin Intermediate Filaments in Transhepatic Transport and Canalicular Secretion

1990 • 36 citations

Identification of a novel glycoprotein (AGp110) involved in interactions of rat liver parenchymal cells with fibronectin.

1990 • 36 citations

Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver

1986 • 36 citations

What is Actin Doing in the Liver Cell?

1983 • 35 citations

Ba2+, TEA+, and quinine effects on apical membrane K+ conductance and maxi K+ channels in gallbladder epithelium

1990 • 35 citations

Secretin empties bile duct cell cytoplasm of vesicles when it initiates ductular HCO3− secretion in the pig

1988 • 35 citations

The bile salt secretory polarity of hepatocytes

1989 • 35 citations

Cellular location of the cleavage event of the polymeric immunoglobulin receptor and fate of its anchoring domain in the rat hepatocyte

1989 • 33 citations

The rat hepatocyte plasma membrane organic anion binding protein is immunologically related to the mitochondrial F1 adenosine triphosphatase beta-subunit.

1990 • 31 citations

Ryanodine receptor in different malignant hyperthermia-susceptible porcine muscles

1991 • 31 citations

Lactosylation of albumin reduces uptake rate of dibromosulfophthalein in perfused rat liver and dissociation rate from albuminIn Vitro

1987 • 29 citations

Subcellular distribution of bile acids, bile salts, and taurocholate binding sites in rat liver

1984 • 29 citations

Chocolate uptake in basolateral rat liver plasma membrane vesicles and in liposomes

1990 • 29 citations

Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis.

1989 • 28 citations

Altered hepatic junctional permeability, bile acid excretion and glutathione efflux during oxidant challenge.

1989 • 27 citations

Bile canalicular contraction in the isolated hepatocyte doublet is related to an increase in cytosolic free calcium ion concentration

1988 • 27 citations

Ursodeoxycholate stimulates Na+-H+ exchange in rat liver basolateral plasma membrane vesicles.

1987 • 27 citations

Norepinephrine-induced cholestasis in the isolated perfused rat liver is secondary to its hemodynamic effects

1990 • 26 citations

Cytosolic bile acid binding protein in rat liver: Radioimmunoassay, molecular forms, developmental characteristics and organ distribution

1986 • 25 citations

Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor

1987 • 25 citations

Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea)

1987 • 23 citations

Mechanisms of Electrolyte Transport in the Liver Their Functional Significance

1985 • 22 citations

Coordination of the contractile activity of bile canaliculi. Evidence from spontaneous contractions in vitro.

1985 • 20 citations

Cryptic na+, k+-atpase activity in rat liver canalicular plasma membranes: Evidence for its basolateral origin

1990 • 19 citations

Vesicular uptake system for the cation lucigenin in the rat hepatocyte.

1989 • 19 citations

Biliary lipid secretion and its control. Effect of taurodehydrocholate

1987 • 18 citations

The membrane fatty acid-binding protein is not identical to mitochondrial glutamic oxaloacetic transaminase (mGOT)

1990 • 15 citations

Purification of a 32.5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids

1986 • 13 citations

Demonstration of vesicular-dependent bile flow in the sucrose-loaded rat

1990 • 11 citations

Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues

1990 • 10 citations

Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes

1989 • 9 citations

Mechanism of cholate uptake: NA+-cotransport, but not cholate/OH− exchange

1990 • 2 citations