Hepatocyte-Specific Mutation Establishes Retinoid X Receptor α as a Heterodimeric Integrator of Multiple Physiological Processes in the Liver

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants

1994 • 987 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Bile acid biosynthesis

1992 • 790 citations

Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation

1992 • 719 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

1994 • 684 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.

1993 • 536 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

1998 • 466 citations

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.

1987 • 443 citations

Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice

1997 • 419 citations

Orphan nuclear receptors—new ligands and new possibilities: Figure 1.

1998 • 301 citations

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

1998 • 285 citations

Nuclear Orphan Receptors Control Cholesterol Catabolism

1999 • 212 citations

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

1996 • 206 citations

Thyroid Hormone Receptor Coactivators and Corepressors

1998 • 122 citations

Distinct Retinoid X Receptor-Retinoic Acid Receptor Heterodimers Are Differentially Involved in the Control of Expression of Retinoid Target Genes in F9 Embryonal Carcinoma Cells

1997 • 117 citations

Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins.

1988 • 103 citations

Binding Specificity and Modulation of the Human ApoCIII Promoter Activity by Heterodimers of Ligand-Dependent Nuclear Receptors

1998 • 51 citations