Molecular identification and functional characterization of Mdr1a in rat cholangiocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene,mdr1a, Spontaneously Develop Colitis

1998 • 570 citations

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1993 • 526 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

1988 • 314 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

1996 • 251 citations

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

1997 • 250 citations

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1988 • 249 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P-Glycoprotein Functioning as an Absorption Barrier

1996 • 229 citations

Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation

1996 • 221 citations

Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver

1989 • 206 citations

Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes

1997 • 165 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

Increased rhodamine 123 uptake by carcinoma cells.

1985 • 151 citations

Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells.

1996 • 140 citations

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

1997 • 134 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.

1993 • 124 citations

Bile secretory function of intrahepatic biliary epithelium in the rat

1989 • 110 citations

Isolation of small polarized bile duct units.

1995 • 107 citations

Glucose reabsorption from bile. Evidence for a biliohepatic circulation.

1974 • 80 citations

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with anmdr1agene disruption

1998 • 78 citations

Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains

1995 • 73 citations

Expression of the multidrug resistance genes in the liver

1997 • 73 citations

Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product p-glycoprotein in primary liver carcinoma

1994 • 72 citations

Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes

1997 • 69 citations

Activation of distinct multidrug‐resistance (P‐glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis

1993 • 64 citations

Role of P-Glycoprotein as a Secretory Mechanism in Quinidine Absorption from Rat Small Intestine

1998 • 63 citations

Up‐Regulation of P‐Glycoprotein Expression in Rat Liver Cells by Acute Doxorubicin Treatment

1997 • 62 citations

Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry

1989 • 57 citations

Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents

1988 • 57 citations

Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells.

1994 • 53 citations

Role of kinases and phosphatases in the regulation of fluid secretion and Cl-/HCO3- exchange in cholangiocytes

1997 • 53 citations

Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats.

1998 • 49 citations

The plasma membrane polarity of human biliary epithelial cells: in situ immunohistochemical analysis and functional implications

1997 • 49 citations

Sugar absorption by the biliary ductular epithelium of the rat: Evidence for two transport systems

1992 • 43 citations

Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells

1996 • 39 citations

Characterization of Apical and Basolateral Plasma Membrane Domains Derived from Cultured Rat Cholangiocytes

1997 • 33 citations

In vitro effect of GF120918, a novel reversal agent of multidrug resistance, on acute leukemia and multiple myeloma cells.

1996 • 29 citations

Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells.

1993 • 29 citations

Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells

1999 • 29 citations

Nitric oxide and guanosine 3?,5?-cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units

1998 • 24 citations

P‐glycoproteins encoded by mdr 1b in murine gravid uterus and multidrug resistant tumor cell lines are differentially glycosylated

1989 • 16 citations