The state of the STATs: recent developments in the study of signal transduction to the nucleus

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

1991 • 499 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Identification of a Stat Gene That Functions in Drosophila Development

1996 • 397 citations

Stat3 and Stat4: members of the family of signal transducers and activators of transcription.

1994 • 396 citations

A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)

1992 • 378 citations

marelle Acts Downstream of the Drosophila HOP/JAK Kinase and Encodes a Protein Similar to the Mammalian STATs

1996 • 375 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

1995 • 300 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3.

1995 • 231 citations

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1995 • 226 citations

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.

1994 • 224 citations

Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor

1996 • 221 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Interactions between STAT and Non-STAT Proteins in the Interferon-Stimulated Gene Factor 3 Transcription Complex

1996 • 203 citations

Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

1995 • 195 citations

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

1993 • 184 citations

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

1996 • 172 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein

1996 • 159 citations

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

1996 • 156 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.

1993 • 112 citations

Identification of the interleukin-6/oncostation M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1)Promoter

1995 • 109 citations

STAT signaling is active during early mammalian development

1997 • 99 citations

IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties.

1995 • 59 citations

Interaction of the Transcriptional Activator Stat-2 with the Type I Interferon Receptor

1995 • 46 citations

IFN-γ induces a p91/Stat1α-related transcription factor with distinct activation and binding properties

1996 • 6 citations