P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

STATs and Gene Regulation

1997 • 3,927 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

The Aryl Hydrocarbon Receptor Complex

1995 • 1,586 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 • 1,157 citations

Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

SXR, a novel steroid and xenobioticsensing nuclear receptor

1998 • 903 citations

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

1998 • 852 citations

IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

1998 • 826 citations

Bile acid biosynthesis

1992 • 790 citations

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

1997 • 789 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

Enzyme induction in the cytochrome P-450 system

1990 • 631 citations

Cytochrome P450 and the Individuality of Species

1999 • 573 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643

1997 • 487 citations

Regulation of Cytochromes P450 During Inflammation and Infection

1997 • 477 citations

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

1994 • 470 citations

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

1998 • 466 citations

Peroxisome proliferator activated receptor-alpha expression in human liver.

1998 • 449 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Cross-Talk between Nuclear Factor-κB and the Steroid Hormone Receptors: Mechanisms of Mutual Antagonism

1998 • 405 citations

Peroxisome Proliferator Activated Receptor-α Expression in Human Liver

1998 • 397 citations

The aryl hydrocarbon receptor: studies using the AHR-null mice.

1998 • 372 citations

DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements

1997 • 367 citations

Steroid hormone receptors and their regulation by phosphorylation

1996 • 361 citations

Expression of Enzymatically Active CYP3A4 by Caco-2 Cells Grown on Extracellular Matrix-Coated Permeable Supports in the Presence of 1α,25-Dihydroxyvitamin D₃

1997 • 326 citations

Peroxisome proliferation and hepatocarcinogenesis

1987 • 310 citations

Orphan nuclear receptors—new ligands and new possibilities: Figure 1.

1998 • 301 citations

Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor

1998 • 293 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene

1999 • 283 citations

Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors

1997 • 279 citations

MINIREVIEW: Proposed Role of Drug-Metabolizing Enzymes: Regulation of Steady State Levels of the Ligands That Effect Growth, Homeostasis, Differentiation, and Neuroendocrine Functions

1991 • 273 citations

Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

1997 • 268 citations

Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARγ

1998 • 256 citations

Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice

1998 • 249 citations

Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.

1995 • 242 citations

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture

1995 • 238 citations

Genes for Cytochrome P-450 and Their Regulatio

1986 • 227 citations

Transcriptional regulation of rat liver epoxide hydratase, NADPH-Cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital.

1983 • 222 citations

Nuclear Orphan Receptors Control Cholesterol Catabolism

1999 • 212 citations

Ah Receptor, a Novel Ligand-Activated Transcription Factor

1997 • 205 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1995 • 185 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain

1999 • 174 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in theCYP2B10Gene

1998 • 160 citations

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1995 • 156 citations

Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression

1999 • 152 citations

Environmental Xenobiotics and the Antihormones Cyproterone Acetate and Spironolactone Use the Nuclear Hormone Pregnenolone X Receptor to Activate theCYP3A23Hormone Response Element

1998 • 150 citations

Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors

1998 • 149 citations

Advances in molecular and cell biology

1992 • 143 citations

Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha)

1998 • 141 citations

Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene

1997 • 139 citations

Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.

1996 • 139 citations

Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.

1996 • 134 citations

Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-α (PPARα) Signaling Pathways

1999 • 133 citations

Mechanisms of Ligand-Induced Aryl Hydrocarbon Receptor-Mediated Biochemical and Toxic Responses

1998 • 129 citations

The Orphan Nuclear Hormone Receptor LXRα Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator Signaling

1996 • 111 citations

Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes

1996 • 109 citations

Down-Regulation of Cytochrome P450 2C Family Members and Positive Acute-Phase Response Gene Expression by Peroxisome Proliferator Chemicals

1998 • 102 citations

Phenobarbital Induction Mediated by a Distal CYP2B2 Sequence in Rat Liver Transiently Transfected in Situ

1996 • 101 citations

PPARα Structure-Function Relationships Derived from Species-Specific Differences in Responsiveness to Hypolipidemic Agents

1997 • 100 citations

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

1998 • 99 citations

Peroxisome proliferator-activated receptor gamma and the control of adipogenesis

1997 • 91 citations

The CYP2B2 Phenobarbital Response Unit Contains an Accessory Factor Element and a Putative Glucocorticoid Response Element Essential for Conferring Maximal Phenobarbital Responsiveness

1998 • 88 citations

Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice.

1993 • 86 citations

The Human Peroxisome Proliferator-activated Receptor (PPAR) Subtype NUC1 Represses the Activation of hPPARα and Thyroid Hormone Receptors

1995 • 85 citations

Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

1994 • 85 citations

Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7)

1995 • 83 citations

Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.

1994 • 82 citations

Inhibition of Peroxisome Proliferator Signaling Pathways by Thyroid Hormone Receptor

1997 • 82 citations

A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

1995 • 79 citations

Conformational Changes in the A1 Domain of von Willebrand Factor Modulating the Interaction with Platelet Glycoprotein Ib

1996 • 79 citations

Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms.

1992 • 79 citations

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif.

1996 • 74 citations

Effect of Transforming Growth Factor-β₁on Expression of Aryl Hydrocarbon Receptor and Genes ofAhGene Battery: Clues for Independent Down-Regulation in A549 Cells

1997 • 74 citations

An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures.

1997 • 69 citations

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

1998 • 69 citations

Regulation of Peroxisome Proliferator-activated Receptor α-Induced Transactivation by the Nuclear Orphan Receptor TAK1/TR4

1998 • 65 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

Characterization of Hepatic-specific Regulatory Elements in the Promoter Region of the Human Cholesterol 7α-Hydroxylase Gene

1997 • 59 citations

Protein Synthesis Inhibitors Exhibit a Nonspecific Effect on Phenobarbital-inducible Cytochome P450 Gene Expression in Primary Rat Hepatocytes

1998 • 55 citations

Coregulatory Proteins in Nuclear Hormone Receptor Action

1998 • 53 citations

Minireview: Regulation of Gene Expression by Nuclear Hormone Receptors

1997 • 52 citations

Nuclear Receptor Involvement in the Regulation of Rat Cytochrome P450 3A23 Expression

1998 • 52 citations

Regulation of steroid receptor subcellular trafficking

1999 • 52 citations

Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole

1991 • 52 citations

Nuclear Hormone Receptors Activate Direct, Inverted, and Everted Repeatsa

1995 • 45 citations

GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C

1996 • 43 citations

The Induction of Five Rat Hepatic P450 Cytochromes by Phenobarbital and Similarly Acting Compounds Is Regulated by a Sexually Dimorphic, Dietary-Dependent Endocrine Factor That Is Highly Strain Specific

1994 • 41 citations

Growth Hormone-Dependent and -Independent Sexually Dimorphic Regulation of Phenobarbital-Induced Hepatic Cytochrome P450 2B1 and -2B2

1994 • 40 citations

Phenobarbital Alters Protein Binding to the CYP2B1/2Phenobarbital-responsive Unit in Native Chromatin

1997 • 38 citations

Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin Iβ, interleukhv 6, and dexamethasone in cultured fetal rat hepatocytes

1997 • 38 citations

Phenobarbital responsiveness conferred by the 5′-flanking region of the rat CYP2B2 gene in transgenic mice

1999 • 37 citations

Regulation of Cytochrome P450 Gene Transcription by Phenobarbital

1998 • 35 citations

Phenobarbital Induction of CYP2B1/2 in Primary Hepatocytes: Endocrine Regulation and Evidence for a Single Pathway for Multiple Inducers

1999 • 32 citations

Nuclear Factor-1 Motif and Redundant Regulatory Elements Comprise Phenobarbital-Responsive Enhancer inCYP2B1/2

1998 • 28 citations

The lithocholic acid 6β-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6β-hydroxylation

1993 • 27 citations

Thyroid Regulation of NADPH:Cytochrome P450 Oxidoreductase: Identification of a Thyroid-Responsive Element in the 5′-Flank of the Oxidoreductase Gene

1997 • 26 citations

Structure-activity relationship of bispyridyloxybenzene for induction of mouse hepatic aminopyrine N-demethylase activity. Chemical, biological, and X-ray crystallographic studies.

1985 • 25 citations

The development and application of a radioimmunoassay for 5α-androst-16-en-3α-ol in plasma

1976 • 18 citations

Characterization of DNA-Binding Proteins Required for Glucocorticoid Induction of CYP3A23

1998 • 17 citations

Effects of phenobarbital and interleukin-6 on cytochrome P4502B1 and 2B2 in cultured rat hepatocytes

1996 • 11 citations

Enhanced differentiation of HL-60 leukemia cells to macrophages induced by ciprofibrate

1998 • 9 citations

In vivo roles of Bm3R1 repressor in the barbiturate-mediated induction of the cytochrome P450 genes (P450BM-3 and P450BM-1) of Bacillus megaterium

1998 • 7 citations