Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

1996 • 1,678 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

1999 • 905 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Split genes and RNA splicing

1994 • 562 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Chemoprotection against cancer by Phase 2 enzyme induction

1995 • 454 citations

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1997 • 396 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

Molecular Characterization and Tissue Distribution of a New Organic Anion Transporter Subtype (oatp3) That Transports Thyroid Hormones and Taurocholate and Comparison with oatp2

1998 • 338 citations

Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain

1999 • 300 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Characterization of inducible nature of MRP3 in rat liver

2000 • 255 citations

Localization and function of the organic anion–transporting polypeptide Oatp2 in rat liver

1999 • 209 citations

Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, and Xenobiotic Regulation

1999 • 196 citations

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

1995 • 189 citations

Quantitative RT-PCR on CYP1A1 Heterogeneous Nuclear RNA: A Surrogate for the In Vitro Transcription Run-On Assay

1996 • 157 citations

Induction of Drug Metabolising Enzymes

2000 • 149 citations

Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse

1996 • 144 citations

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers

1998 • 140 citations

Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells

1999 • 138 citations

Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.

2000 • 129 citations

Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance.

1968 • 109 citations

Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression

1995 • 107 citations

Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?

2001 • 106 citations

Up‐regulation of multidrug resistance‐associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone

1999 • 101 citations

Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators

2000 • 101 citations

Induction ofcMrp/cMoat gene expression by cisplatin, 2- acetylaminofluorene, or cycloheximide in rat hepatocytes

1997 • 90 citations

Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)

1999 • 88 citations

Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats.

1970 • 87 citations

Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.

1974 • 75 citations

Aryl Hydrocarbon Receptor-Inducible or Constitutive Expression of Human UDP Glucuronosyltransferase UGT1A6

1998 • 66 citations

Differential effects of microsomal enzyme–inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2

2001 • 52 citations

The Human Estrogen Receptor Structural Gene Contains a DNA Sequence That Binds Activated Mouse and Human Ah Receptors: A Possible Mechanism of Estrogen Receptor Regulation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1993 • 52 citations

Rabbit pregnane X receptor is activated by rifampicin.

2000 • 46 citations

Processing of gonadotropin-releasing hormone gene transcripts in the rat brain.

1994 • 46 citations

Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction

1970 • 46 citations

Overexpression of mdr2 gene by peroxisome proliferations in the mouse liver

1997 • 41 citations

Induction of cMrp/cMoat gene expression by cisplatin, 2- acetylaminofluorene, or cycloheximide in rat hepatocytes

1997 • 38 citations

Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.

1974 • 33 citations

Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes.

1979 • 25 citations