Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

The multistep nature of cancer

1993 • 1,872 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.

1989 • 523 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.

1976 • 277 citations

Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.

1979 • 252 citations

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids.

1987 • 199 citations

Overexpression of Protein Kinase C in HT29 Colon Cancer Cells Causes Growth Inhibition and Tumor Suppression

1990 • 179 citations

Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free system

1986 • 170 citations

Heterogeneity of cancer cells from a single human colon carcinoma

1981 • 167 citations

A meta-analysis of cholecystectomy and risk of colorectal cancer

1993 • 160 citations

Activation of mast cells by bile acids

1991 • 158 citations

Faecal unconjugated bile acids in patients with colorectal cancer or polyps.

1992 • 137 citations

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas.

1987 • 126 citations

Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

1991 • 117 citations

The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids

1987 • 110 citations

Bile acids, non‐phorbol‐ester‐type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29

1992 • 99 citations

Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes

1993 • 87 citations

Hypotheses for the etiology of colorectal cancer — an overview

1990 • 82 citations

Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control.

1991 • 58 citations

Identification of Two Transcription Factors That Bind to Specific Elements in the Promoter of the Adenovirus Early-Region 4

1988 • 57 citations

Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer

1992 • 53 citations

Roles of endogenous substances and bacteria in colorectal cancer

1993 • 44 citations

Chemotherapy of cell-line-derived human colon carcinomas in mice immunosuppressed with antithymocyte serum

1977 • 43 citations

Studies on Protein Kinase C and Colon Carcinogenesis

1987 • 43 citations

Experimental colorectal cancer: The relationship of diet and faecal bile acid concentration to tumour induction

1986 • 42 citations

Further Biologic Characteristics of a Human Carcinoembryonic Antigen-Producing Colon Carcinoma Cell Line2

1978 • 41 citations

Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas.

1993 • 41 citations

The role of bile acids in colonic carcinogenesis

1985 • 32 citations

Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors

1991 • 32 citations

Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-O-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro.

1992 • 22 citations

Tissue bile acids in patients with colon cancer and colonic polyps.

1982 • 22 citations

Regulation of the Major Histocompatibility Complex Class I mRNA Expression by Bile Acids in Cultured Human Hepatoma Cells

1995 • 18 citations

The effects of bile acids on phospholipase c activity in extracts of normal human colon mucosa and primary colon tumors

1994 • 18 citations

Biliary bile acid profiles in patients with familial adenomatous polyposis before and after colectomy

1994 • 12 citations

Paradoxical derepression of collagenase gene expression by the antirheumatic gold compound aurothiomalate.

1994 • 8 citations