Molecular Pathogenesis of Cholestasis

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis

1998 • 728 citations

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

1998 • 718 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

1997 • 624 citations

Ursodiol for Primary Sclerosing Cholangitis

1997 • 591 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1997 • 502 citations

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.

1994 • 444 citations

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1995 • 419 citations

Mechanisms and regulation of bile secretion

1991 • 402 citations

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1995 • 385 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

1993 • 347 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis

1994 • 325 citations

Hepatic Expression of Class I and Class Ii Major Histocompatibility Complex Molecules in Primary Biliary Cirrhosis: Effect of Ursodeoxycholic Acid

1990 • 311 citations

Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents

1996 • 306 citations

Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis

1996 • 291 citations

Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAJ) gene in liver

1997 • 269 citations

Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): Evidence for heterogeneity

1997 • 268 citations

Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.

1998 • 262 citations

Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion

1997 • 258 citations

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

1996 • 251 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Immunomodulatory Effects of Ursodeoxycholic Acid on Immune Responses

1992 • 235 citations

Molecular aspects of membrane stabilization by ursodeoxycholate

1993 • 212 citations

Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

1997 • 190 citations

Identification of a Locus for Progressive Familial Intrahepatic Cholestasis PFIC2on Chromosome 2q24

1997 • 188 citations

Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei

1997 • 177 citations

The role of mdr2 P‐glycoprotein in hepatobiliary lipid transport

1997 • 167 citations

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene

1996 • 167 citations

Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver

1994 • 165 citations

Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver

1994 • 165 citations

Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis.

1993 • 164 citations

An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer.

1993 • 146 citations

Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.

1993 • 143 citations

Sinusoidal (Basolateral) Bile Salt Uptake Systems of Hepatocytes

1996 • 141 citations

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1996 • 141 citations

Abnormal expression of anion exchanger genes in primary biliary cirrhosis

1993 • 137 citations

Multiple Factors Regulate the Rat Liver Basolateral Sodium-dependent Bile Acid Cotransporter Gene Promoter

1996 • 132 citations

Mapping of a locus for progressive familial intrahepatic cholestasis (Byler disease) to 18q21-q22, the benign recurrent intrahepatic cholestasis region

1995 • 132 citations

Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid

1994 • 131 citations

Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes

1993 • 121 citations

Mechanisms of cholestasis.

1986 • 114 citations

Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets

1995 • 105 citations

Inhibition by cyclosporin A of Adenosine triphosphate-dependent transport from the hepatocyte into bile

1993 • 104 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia

1997 • 99 citations

Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation

1997 • 99 citations

The canalicular conjugate export pump encoded by the cmrp/cmoat gene.

1996 • 92 citations

Morphometric Analysis of Rat Hepatocytes After Total Biliary Obstruction

1976 • 87 citations

A Yeast ATP-binding Cassette-type Protein Mediating ATP-dependent Bile Acid Transport

1997 • 83 citations

Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children

1995 • 81 citations

Severe familial cholestasis in North American Indian children: A clinical model of microfilament dysfunction?

1981 • 78 citations

Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene

1997 • 76 citations

Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat

1993 • 75 citations

Bile duct epithelium: frontiers in transport physiology

1996 • 74 citations

Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver

1996 • 70 citations

Hepatobiliary Disease in Cystic Fibrosis

1994 • 58 citations

Expression of the rat liver Na+/taurocholate cotransporter is regulatedin vivo by retention of biliary constituents but not their depletion

1997 • 58 citations

Ursodeoxycholate increases cytosolic calcium concentration and activates CI− currents in a biliary cell line

1995 • 56 citations

Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes

1994 • 54 citations

Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte

1997 • 52 citations

Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchmal cells

1994 • 51 citations

Transcytotic vesicular carriers for polymeric iga receptors accumulate in rat hepatocytes after bile duct ligation

1991 • 47 citations

Gene therapy: Applications to the treatment of gastrointestinal and liver diseases

1994 • 43 citations

Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity.

1994 • 41 citations

Correction of the cystic fibrosis defect by gene complementation in human intrahepatic biliary epithelial cell lines

1995 • 40 citations

Regulation of intracellular pH in the hepatocyte

1996 • 37 citations

Anion exchanger immunoreactivity in human salivary glands in health and Sjögren's syndrome.

1995 • 35 citations

Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis.

1989 • 28 citations

Isolation of the microtubule-vesicle motor kinesin from rat liver: Selective inhibition by cholestatic bile acids

1995 • 27 citations

Semiquantitation of intrahepatic MDR3 mRNA levels by reverse transcription/competitive polymerase chain reaction

1997 • 24 citations

Calcium signaling mechanisms in liver in health and disease.

1996 • 20 citations

Effects of cholestasis on membrane flow and surface polarity in hepatocytes.

1996 • 15 citations

Regulation of liver-specific gene expression.

1995 • 15 citations

G Proteins in Rat Liver Proliferation During Cholestasis

1994 • 10 citations

Experimental Mallory body formation is accompanied by modulation of the expression of multidrug-resistance genes and their products

1996 • 10 citations

In Search of a Gene for Hereditary Cholestasis

1996 • 6 citations