Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

The Continuing Importance of Bile Acids in Liver and Intestinal Disease

1999 • 870 citations

Absolute mRNA quantification using the polymerase chain reaction (PCR). A novel approach by aPCR aidedtranscipttitration assay (PATTY)

1989 • 659 citations

Molecular Pathogenesis of Cholestasis

2004 • 622 citations

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1997 • 502 citations

Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte

1990 • 391 citations

Up-regulation of the multidrug resistance genes,Mrp1andMdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver

1998 • 361 citations

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases

2001 • 354 citations

High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids

1987 • 322 citations

Functions of c-Jun in Liver and Heart Development

1999 • 274 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion

1997 • 258 citations

Expression of the bile salt export pump is maintained after chronic cholestasis in the rat

2000 • 251 citations

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

1996 • 251 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C–dependent mechanisms in cholestatic rat liver

2001 • 246 citations

In situ localization of the hepatocytic na+/taurocholate cotransporting polypeptide in rat liver

1994 • 221 citations

Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications

1998 • 218 citations

Transport Function and Hepatocellular Localization of mrp6 in Rat Liver

2000 • 218 citations

Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

1997 • 190 citations

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene

1996 • 167 citations

Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis.

1993 • 164 citations

Ursodeoxycholic Acid Protects Hepatocytes against Oxidative Injury via Induction of Antioxidants

1999 • 164 citations

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1996 • 141 citations

Abnormal expression of anion exchanger genes in primary biliary cirrhosis

1993 • 137 citations

The simultaneous extraction of high-molecular-weight DNA and of RNA from solid tumors

1983 • 136 citations

The Role of Phosphoinositide 3-Kinase in Taurocholate-induced Trafficking of ATP-dependent Canalicular Transporters in Rat Liver

1998 • 131 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Molecular cloning and characterization of the murine bile salt export pump

2000 • 124 citations

Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease

1992 • 121 citations

Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: pathophysiology of biliary lipid secretion

1999 • 117 citations

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1997 • 115 citations

A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domain.

1983 • 111 citations

Assessment of Biliary Bicarbonate Secretion in Humans by Positron Emission Tomography

2017 • 106 citations

Role of Vesicle-Mediated Transport Pathways in Hepatocellular Bile Secretion

1996 • 104 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation

1997 • 99 citations

Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria

1999 • 98 citations

Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis

1999 • 97 citations

Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice☆☆☆

1998 • 94 citations

Short-Term Regulation of Canalicular Transport

2000 • 84 citations

Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children

1995 • 81 citations

Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid

1997 • 76 citations

Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X

1999 • 71 citations

Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver

2000 • 54 citations

Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver

1999 • 53 citations

Biliary secretion of bile acids and lipids in primary sclerosing cholangitis.Influence of cholestasis and effect of ursodeoxycholic acid treatment

1995 • 51 citations

Full-Length cDNA Cloning and Genomic Organization of the Mouse Liver-Specific Organic Anion Transporter-1 (lst-1)

2000 • 44 citations

[32] Absolute levels of mRNA by polymerase chain reaction-aided transcript titration assay

1993 • 35 citations

Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice

1999 • 29 citations

Molecular cloning of the murine cMOAT ATPase

2000 • 23 citations

Disturbance of keratin homeostasis in griseofulvin-intoxicated mouse liver.

1993 • 23 citations

Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding

1995 • 20 citations

Molecular cloning and functional analysis of the promoter for bile salt export pump (BSEP) from human and mouse genes: Evidence for transactivation of the humanpromoter by farnesoid-x-receptor/retinoid-x-receptor(FXR/RXR)

2000 • 5 citations

TNF-alpha mediated up-regulation of the multidrug resistance gene mdr1b but not of mrp1 in rat hepatocytes is dependent on NF-kappa B activation

1999 • 2 citations