Redundant Pathways for Negative Feedback Regulation of Bile Acid Production

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

2000 • 1,801 citations

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

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2001 • 1,271 citations

Bile acid biosynthesis

1992 • 790 citations

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

2001 • 772 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis

2000 • 734 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

1996 • 535 citations

Regulation of bile acid synthesis

1998 • 379 citations

Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4

2000 • 341 citations

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

1995 • 332 citations

Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway

2001 • 319 citations

The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

2000 • 303 citations

CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene

1999 • 283 citations

Control of Cholesterol Turnover in the Mouse

2002 • 265 citations

Nuclear Orphan Receptors Control Cholesterol Catabolism

1999 • 212 citations

The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

1999 • 179 citations

Identification and Characterization of a Mouse Oxysterol 7α-Hydroxylase cDNA

1997 • 159 citations

Three distinct types of GnRH receptor characterized in the bullfrog

2000 • 158 citations

The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors

2000 • 157 citations

Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner

2002 • 152 citations

Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)

1998 • 139 citations

Novel Receptor Interaction and Repression Domains in the Orphan Receptor SHP

1997 • 133 citations

Structure and Expression of the Orphan Nuclear ReceptorSHP Gene

1998 • 109 citations

Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

2001 • 109 citations

Two 7α‐hydroxylase enzymes in bile acid biosynthesis

1998 • 105 citations

Activation of the Promoter of the Orphan Receptor SHP by Orphan Receptors That Bind DNA as Monomers

1999 • 103 citations

Cholesterol is converted to 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7 alpha-hydroxylase.

1992 • 57 citations

An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors

1997 • 56 citations

A Novel Nonhepatic Hydroxycholesterol 7α-Hydroxylase That Is Markedly Stimulated by Interleukin-1β

1995 • 43 citations