Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

The Kidney: Physiology and Pathophysiology

1992 • 1,714 citations

HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY

1969 • 940 citations

A principle for counting tissue structures on random sections

1962 • 819 citations

A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Biliary Cirrhosis

1991 • 727 citations

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

1988 • 314 citations

Direct spectrophotometry of total bile acids in serum.

1981 • 271 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.

1993 • 251 citations

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter.

1997 • 250 citations

Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver

1989 • 206 citations

Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes

1997 • 165 citations

Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation

1994 • 141 citations

Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion

1996 • 139 citations

Production of bile duct hyperplasia and gallstones by lithocholic acid.

1966 • 131 citations

Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster

1984 • 128 citations

Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes

1997 • 125 citations

Effect of dietary chenodeoxycholic acid and lithocholic acid in the rabbit

1974 • 99 citations

Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes

1997 • 85 citations

Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase

1994 • 71 citations

Modulation of rat hepatocyte proliferation by bile salts: In vitro and In vivo studies

1996 • 60 citations

Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells

1997 • 45 citations

Feedback regulation of bile acid synthesis in the rat by dietary vs. Intravenous cholate or taurocholate

1988 • 35 citations

Improved method for measuring the glycine and taurine conjugates of bile salts by high-performance liquid chromatography with tauro-7α,12α-dihydroxy-5β-cholanic acid as internal standard

1987 • 33 citations

Effect of chronic administration of taurolithocholate on bile formation and liver ultrastructure in the rat

1987 • 9 citations

The protective effect of hydrophilic bile acids on bile acid hepatotoxicity in the rat.

1995 • 6 citations

Ursodeoxycholic acid feeding inhibits secretin-induced cholangiocyte secretory processes in bile duct ligated rats

1998 • 5 citations

Stimulatory Effect of Ursodeoxycholate on Pancreatic Exocrine Secretion in an In Vitro Study

1995 • 3 citations