Genetic and Mutational Analysis of the T-Cell Antigen Receptor

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.

1981 • 419 citations

Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein

1985 • 287 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Biological Effects of Staphylococcal Enterotoxin A on Human Peripheral Lymphocytes

1978 • 236 citations

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.

1986 • 191 citations

Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes

1986 • 188 citations

The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

1987 • 148 citations

Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.

1988 • 146 citations

TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes.

1986 • 144 citations

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

1987 • 141 citations

The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

1988 • 131 citations

Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

1989 • 128 citations

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

1988 • 128 citations

Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).

1987 • 124 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Biosynthesis and molecular nature of the T3 antigen of human T lymphocytes.

1983 • 110 citations

Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.

1987 • 107 citations

Studies of the mouse Ly-6 alloantigen system

1984 • 105 citations

Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.

1988 • 103 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

Activation-Driven Programmed Cell Death and T Cell Receptor ζη Expression

1989 • 98 citations

Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.

1988 • 94 citations

A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen

1988 • 93 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

1987 • 88 citations

Physical linkage of three CD3 genes on human chromosome 11.

1987 • 87 citations

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.

1987 • 86 citations

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

1988 • 84 citations

Genetic nomenclature for loci controlling mouse lymphocyte antigens

1987 • 76 citations

Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation.

1987 • 74 citations

Activation induces a rapid reorganization of spectrin in lymphocytes

1988 • 71 citations

Transfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure.

1988 • 53 citations

Activation of murine T lymphocytes with monoclonal antibodies: detection on Lyt-2+ cells of an antigen not associated with the T cell receptor complex but involved in T cell activation.

1987 • 51 citations

Association and dissociation of the murine T cell receptor associated protein (TRAP). Early events in the biosynthesis of a multisubunit receptor.

1988 • 49 citations

Studies of the mouse Ly-6 alloantigen system

1980 • 47 citations

T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule, TAP.

1988 • 44 citations

Analysis of the mitogenic effects of toxic shock toxin on human peripheral blood mononuclear cells in vitro

1984 • 43 citations

At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

1988 • 42 citations

Demonstration of phosphatidylinositol anchors on Ly-6 molecules by specific phospholipase C digestion and gel electrophoresis in octylglucoside

1987 • 38 citations

Antigenic, functional, and molecular genetic studies of human natural killer cells and cytotoxic T lymphocytes not restricted by the major histocompatibility complex.

1986 • 34 citations

CD2 and CD3 antigens mobilize Ca²⁺ independently

1986 • 31 citations

Stable expression of the cDNA encoding the human T lymphocyte‐specific CD2 antigen in murine L cells

1988 • 11 citations