In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment.

Antileukemic Effect of Chronic Graft-versus-Host Disease

1981 • 1,112 citations

Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.

1985 • 737 citations

Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts

1985 • 517 citations

MONOCLONAL ANTIBODIES TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS

1982 • 471 citations

DEPLETION OF T LYMPHOCYTES IN DONOR MARROW PREVENTS SIGNIFICANT GRAFT-VERSUS-HOST DISEASE IN MATCHED ALLOGENEIC LEUKAEMIC MARROW TRANSPLANT RECIPIENTS

1984 • 362 citations

Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance.

1985 • 269 citations

Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection.

1987 • 242 citations

GRAFT REJECTION IN RECIPIENTS OF T-CELL-DEPLETED HLA-NONIDENTICAL MARROW TRANSPLANTS FOR LEUKEMIA

1987 • 241 citations

Mortality and Gross Pathology of Secondary Disease in Germfree Mouse Radiation Chimeras

1971 • 205 citations

Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants.

1988 • 195 citations

Production of hematopoietic colony-stimulating factors by human natural killer cells.

1989 • 193 citations

Acute rejection of murine bone marrow allografts by natural killer cells and T cells. Differences in kinetics and target antigens recognized.

1987 • 175 citations

Antibacterial activity of human natural killer cells.

1989 • 163 citations

Graft-versus-leukemia following bone marrow transplantation.

1987 • 149 citations

Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.

1980 • 138 citations

Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10.D2----B10).

1986 • 136 citations

Role of Bacterial Microflora in Development of Intestinal Lesions From Graft-Versus-Host Reaction

1977 • 132 citations

Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts.

1988 • 104 citations

Toxicity and therapeutic efficacy of high-dose interleukin 2. In vivo infusion of antibody to NK-1.1 attenuates toxicity without compromising efficacy against murine leukemia.

1989 • 103 citations

Intraperitoneal Administration of Interleukin-2 in Patients With Cancer

1986 • 91 citations

Fc (IgG) receptors on rat basophilic leukemia cells.

1981 • 87 citations

Systemic administration of recombinant human interleukin-2 in mice.

1984 • 85 citations

T cell depletion in bone marrow transplantation.

1988 • 85 citations

In vivo induction of the lymphokine-activated killer phenomenon: interleukin 2-dependent human non-major histocompatibility complex-restricted cytotoxicity generated in vivo during administration of human recombinant interleukin 2.

1988 • 82 citations

Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. I. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component.

1988 • 74 citations

Monoclonal anti-H-2Kb antibodies detect serological differences betweenH-2K b mutants

1981 • 74 citations

Cloned natural suppressor cells prevent lethal graft-vs-host disease.

1987 • 72 citations

Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD.

1988 • 67 citations

GRAFT-VERSUS-HOST REACTIONS IN THE BEIGE MOUSE

1987 • 60 citations

T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

1986 • 52 citations

Adoptive immunotherapy in conjunction with bone marrow transplantation--amplification of natural host defence mechanisms against cancer by recombinant IL-2.

1988 • 48 citations

Role of lymphokine-activated killer cells as mediators of veto and natural suppression.

1988 • 43 citations

LETHAL MURINE GRAFT-VERSUS-HOST DISEASE IN THE ABSENCE OF DETECTABLE CYTOTOXIC T LYMPHOCYTES

1983 • 40 citations

In vitro propagation and cloning of murine natural suppressor (NS) cells.

1984 • 38 citations

Physical, biologic, and phenotypic properties of natural regulatory cells in murine bone marrow

1982 • 36 citations

Heterogeneity of lymphokine-activated killer cells induced by IL-2. Separate lymphoid subpopulations lyse tumor, allogeneic blasts, and modified syngeneic blasts.

1988 • 35 citations

Graft-versus-leukemia effect using mixed allogeneic bone marrow transplantation.

1989 • 33 citations

Lymphokine-activated killer cells derived from murine bone marrow: Age-associated difference in precursor cell populations demonstrated by response to interferon

1988 • 14 citations

Lymphokine-activated killer cells in rats: Generation of natural killer cells and lymphokine-activated killer cells from bone marrow progenitor cells

1989 • 12 citations

In vitro and in vivo cytokine-induced facilitation of immunohematopoietic reconstitution in mice undergoing bone marrow transplantation.

1988 • 12 citations