The effect of tumor necrosis factor α and γ‐interferon on the resorption of human articular cartilage and on the production of prostaglandin e and of caseinase activity by human articular chondrocytes

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. ii. low levels of synovial fluid and synovial tissue interferon suggest that γgm‐interferon is not the primary macrophage activating factor

1987 • 177 citations

Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma

1986 • 151 citations

Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon.

1985 • 79 citations

Modulation of connective tissue metabolism by partially purified human interleukin 1

1985 • 49 citations

Changes in cell surface antigen expression on human articular chondrocytes induced by gamma‐interferon

1987 • 47 citations

Retinoids and synovial factor(s) stimulate the production of plasminogen activator by cultured human chondrocytes. A possible role for plasminogen activator in the resorption of cartilage in vitro

1985 • 31 citations

DIMINISHED IL-2-INDUCED GAMMA-INTERFERON PRODUCTION BY UNSTIMULATED PERIPHERAL-BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS

1988 • 17 citations

Homogeneous interferon-β-inducing 22K factor (IL-1β) has connective tissue cell stimulating activities

1986 • 14 citations