TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

The isolation and characterization of the human suppressor inducer T cell subset.

1985 • 860 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

The isolation and characterization of the human helper inducer T cell subset.

1985 • 708 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

1968 • 668 citations

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

1966 • 613 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

IgG2a restriction of murine antibodies elicited by viral infections.

1987 • 429 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

1988 • 359 citations

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

1985 • 356 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

‘B-cell factors’ are pleiotropic

1988 • 230 citations

The Relationship Between Humoral and Cell‐Mediated Immunity

1972 • 228 citations

T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

1986 • 218 citations

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

1987 • 212 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

1976 • 208 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice.

1988 • 199 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

1986 • 194 citations

The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin.

1984 • 193 citations

Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.

1986 • 186 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Subpopulations of Thymus Cells and Thymus-Derived Lymphocytes

1971 • 176 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-gamma.

1988 • 170 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

1984 • 152 citations

Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.

1982 • 145 citations

Phenotypic and functional heterogeneity of CD4+ T cells

1988 • 142 citations

B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.

1987 • 141 citations

Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

1985 • 141 citations

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

1987 • 140 citations

Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells.

1987 • 137 citations

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

1977 • 130 citations

Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages.

1987 • 128 citations

The Role of IL4 and IL5: Characterization of a Distinct Helper T Cell Subset that makes IL4 and IL5 (Th2) and Requires Priming before Induction of Lymphokine Secretion

1988 • 123 citations

Opposing effects of glucocorticoids on interferon-gamma-induced murine macrophage Fc receptor and Ia antigen expression.

1985 • 123 citations

H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2.

1976 • 120 citations

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

1987 • 120 citations

Enhancement of IgG anti‐carrier responses by IgG₂ anti‐hapten antibodies in mice

1985 • 110 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

Functional heterogeneity among the T-derived lymphocytes of the mouse. I. Analysis by adult thymectomy.

1974 • 105 citations

B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.

1987 • 105 citations

Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression.

1979 • 102 citations

Immunopathology of parasitic diseases: Involvement of basophils and mast cells

1980 • 102 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice

1975 • 93 citations

T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.

1983 • 93 citations

Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity.

1984 • 84 citations

Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.

1987 • 82 citations

Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.

1975 • 77 citations

Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.

1988 • 75 citations

Mast cells in severely T-cell depleted rats and the response to infestation with Nippostrongylus brasiliensis.

1979 • 70 citations

Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones.

1984 • 69 citations

Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

1979 • 60 citations

Interaction and Activation of Antigen‐Specific T and B Cells

1987 • 59 citations

B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

1987 • 56 citations

Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate.

1987 • 55 citations

Intestinal Mast Cell and Eosinophil Numbers During Worm Expulsion in Nulliparous and Lactating Rats Infected with <i>Nippostrongylus brasiliensis</i>

1972 • 53 citations

Increased autoantibody production by NZB/NZW B cells in response to IL-5.

1988 • 52 citations

Specific antibody-mediated effect on the immune response. Suppression and augmentation of the primary immune response in mice by different classes of antibodies.

1972 • 50 citations

Clearance of interleukin 2 from the blood of normal and T cell‐depleted mice

1982 • 49 citations

Functional heterogeneity among the T-derived lymphocytes of the mouse. II. Sensitivity of subpopulations to anti-thymocyte serum.

1975 • 49 citations

Antigen-specific helper T-cell clone supernatant is sufficient to induce both polyclonal proliferation and differentiation of small resting B lymphocytes.

1984 • 48 citations

Reaginic antibodies and helminth infection

1973 • 47 citations

The role of B cell surface Ia antigen recognition by T cells in B cell triggering. Analysis of the interaction of cloned helper T cells with normal B cells in differing states of activation and with B cells expressing the xid defect

1984 • 46 citations

Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

1987 • 46 citations

Autocrine growth inhibition of a cloned line of helper T cells.

1986 • 45 citations

Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response.

1977 • 36 citations

Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4.

1988 • 36 citations

Murine T-cell clones specific for chicken erythrocyte alloantigens

1986 • 33 citations

Restriction in the function of single helper T cells.

1976 • 25 citations

Reciprocity in Lymphocyte Interactions

1987 • 24 citations

Cell-Mediated and Humoral Immune Responses in Mice

1977 • 23 citations

Antigen- and Lectin-Sensitized Murine Cytolytic T Lymphocyte-Precursors Require Both Interleukin 2 and Endogenously Produced Immune (γ) Interferon for Their Growth and Differentiation into Effector Cells

1986 • 23 citations

Thymus‐Dependent Antigenic Stimulation of Hapten‐Specific B Lymphocytes

1987 • 20 citations

A cloned, antigen-specific, Ia-restricted Lyt-1+,2- T cell with suppressive activity.

1983 • 19 citations

Antigen presentation by hapten‐specific B lymphocytes III. Analysis of the immunoglobulin‐dependent pathway of antigen presentation to interleukin 1‐dependent T lymphocytes

1986 • 17 citations

Characterization of murine cytolytic-helper hybrid T cell clones

1987 • 16 citations

A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion.

1985 • 16 citations

Suppression of IgE antibody production in SJL mice. IV. Interaction of primed and unprimed T cells.

1979 • 12 citations

Functional heterogeneity among the T-derived lymphocytes of the mouse. VII. Conversion of T1 cells to T2 cells by antigen.

1977 • 11 citations

Biochemical characterization and biological effects of partially purified b cell‐activating factor (bcaf)

1988 • 7 citations