Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1983 • 1,143 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Interleukin-2 augments natural killer cell activity

1981 • 921 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

1984 • 742 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor.

1981 • 516 citations

Interleukin 2

1984 • 497 citations

Expression of interleukin 2 receptors on activated human B cells.

1984 • 488 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).

1985 • 373 citations

Expression of Tac antigen on activated normal human B cells.

1984 • 355 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes

1987 • 301 citations

Cloning, sequence and expression of human interleukin-2 receptor

1984 • 272 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

1986 • 251 citations

Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor.

1987 • 234 citations

Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.

1989 • 219 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells.

1986 • 192 citations

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

1988 • 183 citations

Only high-affinity receptors for interleukin 2 mediate internalization of ligand.

1986 • 174 citations

Functional and Molecular Aspects of Human T Lymphocyte Activation via T3‐Ti and Tl1 Pathways

1987 • 152 citations

Reconstitution of functional receptor for human interleukin-2 in mouse cells

1985 • 150 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

1988 • 137 citations

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

1985 • 119 citations

Contribution of a p75 interleukin 2 binding peptide to a high-affinity interleukin 2 receptor complex.

1987 • 115 citations

A model system for peptide hormone action in differentiation: Interleukin 2 induces a B lymphoma to transcribe the J chain gene

1986 • 104 citations

Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.

1988 • 99 citations

Molecular Analysis of the Interleukin‐2 System

1986 • 89 citations

Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection

1986 • 80 citations

Conversion of low-affinity interleukin 2 receptors to a high-affinity state following fusion of cell membranes.

1986 • 64 citations

Direct identification of the murine IL-2 receptor p55-p75 heterodimer in the absence of IL-2.

1988 • 40 citations

Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus.

1985 • 37 citations

Expression and functional characterization of artificial mutants of interleukin-2 receptor

1987 • 31 citations

Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules.

1987 • 23 citations

Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?

1988 • 19 citations