In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp‐lpr/lpr mouse

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Nucleotide sequence of a full-length cDNA for mousecytosketetal β-actin raRNA

1986 • 556 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants

1982 • 295 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

Organ‐Specific Autoimmunity: A 1986 Overview

1986 • 274 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene.

1981 • 237 citations

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

1987 • 236 citations

The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice.

1988 • 232 citations

[33] First-strand cDNA synthesis primed with oligo(dT)

1987 • 220 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

1985 • 178 citations

Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

1988 • 174 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

1987 • 121 citations

Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals.

1988 • 119 citations

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.

1985 • 101 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Functional analysis of T cell subsets from mice bearing the lpr gene.

1985 • 87 citations

Recombinant human tumour necrosis factor (rTNF)2 enhances leukotriene biosynthesis in neutrophils and eosinophils stimulated with the Ca2+ ionophore A23187.

1987 • 72 citations

Studies of congenic MRL-Ipr/Ipr.xid mice.

1983 • 72 citations

Modulation of the growth of transformed cells by human tumor necrosis factor-alpha and interferon-gamma.

1987 • 71 citations

Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones.

1984 • 69 citations

The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.

1989 • 66 citations

Spontaneous production of interleukin 3 by T lymphocytes from autoimmune MRL/MP‐lpr/lpr mice

1984 • 59 citations

The abnormal T lymphocytes in lpr mice transcribe interferon‐γ and tumor necrosis factor‐α genes spontaneously in vivo

1989 • 59 citations

The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation.

1988 • 57 citations

The cellular basis for immune interferon production in autoimmune MRL-Ipr/Ipr mice.

1983 • 51 citations

The role of L3T4⁺ cells in the pathogenesis of lupus in lpr‐bearing mice. I. Defects in the production of interleukins 2 and 3

1987 • 41 citations

Production of interleukin 2, interleukin 3, and interferon by mouse T lymphocyte clones of Lyt-2+ and -2- phenotype.

1984 • 38 citations

The murine tumor necrosis factor-beta (lymphotoxin) gene sequence

1987 • 34 citations

Expression of lymphokine genes in splenic lymphocytes of autoimmune mice

1989 • 29 citations

A new T cell subset expressing B220 and CD4 in lpr mice: defects in the response to mitogens and in the production of IL-2.

1988 • 24 citations

A unique monoclonal antibody derived from a lupus-prone mouse with multiple bindings to autoantigens associated with rheumatic disease

1988 • 16 citations

Correction of defective IL 3 responses of T lymphocytes from autoimmune mice.

1986 • 11 citations

Inability of autoimmune mice with the lpr gene to spontaneously produce interleukin 3

1986 • 10 citations

Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium lonophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c

1988 • 4 citations

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