Calcium and T lymphocyte activation

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Calcium Rises Abruptly and Briefly Throughout the Cell at the Onset of Anaphase

1986 • 541 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

1989 • 431 citations

Molecular model for receptor-stimulated calcium spiking.

1988 • 416 citations

Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulum

1988 • 399 citations

Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

1987 • 356 citations

A Spatial-Temporal Model of Cell Activation

1988 • 347 citations

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

1984 • 308 citations

Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate

1988 • 307 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

1989 • 259 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.

1986 • 191 citations

Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in a hepatic plasma membrane fraction.

1988 • 178 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex.

1987 • 168 citations

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

1988 • 167 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

TEA prevents inactivation while blocking open K+ channels in human T lymphocytes

1989 • 165 citations

Inositol 1,3,4,5-Tetrakisphosphate Induces Ca ²⁺ Sequestration in Rat Liver Cells

1988 • 165 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.

1988 • 146 citations

Role of calcium fluxes in the sustained phase of angiotensin II-mediated aldosterone secretion from adrenal glomerulosa cells.

1985 • 141 citations

The localization of calcium release by inositol trisphosphate in Limulus photoreceptors and its control by negative feedback

1988 • 138 citations

Inositol trisphosphate isomers, but not inositol 1,3,4,5-tetrakisphosphate, induce calcium influx in Xenopus laevis oocytes.

1988 • 129 citations

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction

1987 • 121 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells.

1986 • 98 citations

Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes.

1987 • 96 citations

Antigen-dependent increase in cytosolic free calcium in specific human T-lymphocyte clones

1985 • 92 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Opening of dihydropyridine calcium channels in skeletal muscle membranes by inositol trisphosphate

1988 • 80 citations

Inositol trisphosphate activates a voltage-dependent calcium influx in Xenopus oocytes

1987 • 72 citations

Antigen-specific T cell activation results in an increase in cytoplasmic free calcium.

1985 • 66 citations

Pertussis toxin triggers rapid second messenger production in human T lymphocytes.

1987 • 59 citations

The role of K+ in the regulation of the increase in intracellular Ca2+ mediated by the T lymphocyte antigen receptor

1987 • 48 citations

Triggering of T-lymphocytes via Either T3-Ti or T11 Surface Structures Opens a Voltage-insensitive Plasma Membrane Calcium-permeable Channel: Requirement for Interleukin-2 Gene Function

1989 • 46 citations

Spatial and temporal characteristics of the increase in intracellular Ca2+ induced in cytotoxic T lymphocytes by cellular antigen.

1988 • 38 citations

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes.

1988 • 30 citations

Activation of mouse spleen cells by a single short pulse of mitogen

1977 • 30 citations

Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells.

1987 • 23 citations

Two episodes of calcium uptake associated with T-lymphocyte activation

1988 • 20 citations

Inhibition of the CD3-mediated calcium signal by protein kinase C activators in human T (Jurkat) lymphoblastoid cells

1989 • 17 citations