Phospholipase D—Structure, regulation and function
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Abstract
References (390)
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
1999 • 1,484 citations
Diversity of group types, regulation, and function of phospholipase A2.
1994 • 1,444 citations
Signaling through phosphatidylcholine breakdown.
1990 • 1,362 citations
Glucosylation of Rho proteins by Clostridium difficile toxin B
1995 • 1,025 citations
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
2001 • 1,012 citations
Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis
1996 • 998 citations
ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
1993 • 900 citations
Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation
1999 • 800 citations
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
1997 • 698 citations
Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family
1995 • 663 citations
The bioactive phospholipid lysophosphatidic acid is released from activated platelets
1993 • 653 citations
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
1994 • 647 citations
Phospholipase D: a Downstream Effector of ARF in Granulocytes
1994 • 636 citations
Transphosphatidylation by Phospholipase D
1967 • 563 citations
Characterization of Two Alternately Spliced Forms of Phospholipase D1
1997 • 547 citations
Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography.
1982 • 533 citations
ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex
1999 • 513 citations
Signal transduction through lipid second messengers
1996 • 496 citations
ADP-Ribosylation Factor 6 Regulates a Novel Plasma Membrane Recycling Pathway
1997 • 494 citations
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
1987 • 472 citations
Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly
1995 • 443 citations
Regulation of Phospholipase D2: Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins
1998 • 427 citations
The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein
1993 • 422 citations
Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid
1994 • 410 citations
Phospholipase D: enzymology, mechanisms of regulation, and function
1997 • 405 citations
Lysophosphatidic Acid Receptors
2000 • 404 citations
Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid
1996 • 402 citations
Phosphatidic acid: an emerging plant lipid second messenger
2001 • 385 citations
Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.
1996 • 380 citations
Regulation of phospholipase D
1999 • 369 citations
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.
1992 • 368 citations
Regulation of Phosphoinositide Phospholipases by Hormones, Neurotransmitters, and Other Agonists Linked to G Proteins
1996 • 362 citations
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity
1997 • 354 citations
Molecules in the ARF Orbit
1998 • 346 citations
Metabolism of Molecular Species of Diacylglycerophospholipids
1978 • 331 citations
A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues
1996 • 318 citations
Mammalian phospholipase D structure and regulation
1999 • 311 citations
Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids
1994 • 308 citations
Biochemical dissection of AP-1 recruitment onto Golgi membranes.
1993 • 308 citations
The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras
2000 • 307 citations
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.
1988 • 307 citations
Signalling sphingomyelinases: which, where, how and why?11With the participation of Nathalie Andrieu-Abadie, Nathalie Augé, Bruno Ségui, Emmanuelle Uro-Coste, Robert Salvayre, INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910 Toulouse Cedex 4, France, and Christine Bezombes, Véronique Mansat-De Mas, INSERM CJF 9503, Institut Claudius Régaud, Toulouse, France.
1999 • 305 citations
Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.
1985 • 304 citations
The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids
1989 • 287 citations
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.
1994 • 277 citations
Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton
1993 • 277 citations
The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P2 influences cytoskeletal protein activity at the plasma membrane
2000 • 271 citations
Involvement of Ral GTPase in v-Src-induced phospholipase D activation
1995 • 261 citations
Activation of a Novel Calcium-dependent Protein-tyrosine Kinase
1996 • 256 citations
Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species
2000 • 255 citations
Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.
1986 • 254 citations
Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.
1987 • 253 citations
The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3
1989 • 252 citations
Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity
1996 • 251 citations
Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network
1997 • 251 citations
Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins
1996 • 250 citations
Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.
1994 • 250 citations
Regulation of Phospholipase D in HL-60 Granulocytes
1989 • 250 citations
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.
1994 • 245 citations
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells
2001 • 238 citations
Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.
1992 • 237 citations
Intracellular Distribution of Arf Proteins in Mammalian Cells
1996 • 235 citations
Cloning and Initial Characterization of a Human Phospholipase D2 (hPLD2)
1998 • 234 citations
Choline-linked Phosphoglycerides
1989 • 234 citations
Regulation and function of the Rho subfamily of small GTPases
1994 • 233 citations
Cloning, Expression, and Characterization of a Novel Phospholipase D Complementary DNA from Rat Brain
1997 • 227 citations
Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.
1986 • 217 citations
Role for Phospholipase D in Receptor-Mediated Endocytosis
2001 • 216 citations
Stimulation of actin stress fibre formation mediated by activation of phospholipase D
1996 • 215 citations
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.
1996 • 215 citations
Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.
1993 • 213 citations
Crystal structure of a phospholipase D family member.
1999 • 212 citations
The small GTP-binding protein Rho links G protein-coupled receptors and Gα 12 to the serum response element and to cellular transformation
1997 • 211 citations
Rhodopsin-family receptors associate with small G proteins to activate phospholipase D
1998 • 211 citations
Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.
1988 • 207 citations
Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation
1996 • 206 citations
Biologically active lipids are regulators of Rac.GDI complexation.
1993 • 206 citations
Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil
1989 • 204 citations
Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions
1997 • 200 citations
Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation
1998 • 200 citations
Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.
1992 • 195 citations
Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.
1995 • 193 citations
Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.
1994 • 188 citations
Intracellular Localization of Phospholipase D1 in Mammalian Cells
2001 • 183 citations
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol
1993 • 182 citations
The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.
1993 • 181 citations
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin
1993 • 179 citations
Type I Phosphatidylinositol 4-Phosphate 5-Kinase Directly Interacts with ADP-ribosylation Factor 1 and Is Responsible for Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Golgi Compartment
2000 • 177 citations
Diacylglycerol – when is it an intracellular messenger?
1998 • 176 citations
Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.
1993 • 175 citations
Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex
1997 • 174 citations
Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes
1999 • 174 citations
The first crystal structure of a phospholipase D
2000 • 171 citations
Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways
1996 • 171 citations
Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts
1998 • 171 citations
Structural Analysis of Human Phospholipase D1
1999 • 169 citations
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals
1993 • 167 citations
Constitutively Active Gα12, Gα13, and Gαq Induce Rho-dependent Neurite Retraction through Different Signaling Pathways
1998 • 166 citations
Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface
1999 • 165 citations
Regulated Exocytosis in Chromaffin Cells
1998 • 165 citations
Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.
1991 • 165 citations
Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists
2001 • 163 citations
ARF signaling: A potential role for phospholipase D in membrane traffic
1993 • 161 citations
Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts
1989 • 161 citations
Molecular Heterogeneity of Phospholipase D (PLD)
1997 • 161 citations
Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil
1992 • 160 citations
ARF and PITP restore GTPγS-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis
1996 • 160 citations
Molecular Analysis of Mammalian Phospholipase D2
1999 • 157 citations
Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA
1997 • 155 citations
Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
1995 • 153 citations
Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils
1990 • 151 citations
Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor
1996 • 151 citations
Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate
1998 • 150 citations
Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts
1996 • 149 citations
Phosphatidate-dependent protein phosphorylation.
1991 • 149 citations
Regulated Exocytosis in Chromaffin Cells
1997 • 148 citations
Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis
1989 • 146 citations
Carbachol-stimulated Transactivation of Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase in T84 Cells Is Mediated by Intracellular Ca2+, PYK-2, and p60
2000 • 145 citations
Localization and possible functions of phospholipase D isozymes
1999 • 145 citations
Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells
1995 • 145 citations
Partial Purification and Characterization of Arf-sensitive Phospholipase D from Porcine Brain
1995 • 143 citations
Phosphatidic Acid-mediated Phosphorylation of the NADPH Oxidase Component p47-phox
1997 • 140 citations
Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
1982 • 140 citations
Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D
1995 • 139 citations
Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.
1992 • 139 citations
Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.
1988 • 138 citations
Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels
1998 • 138 citations
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain
2000 • 137 citations
ARF1 Regulates pH-dependent COP Functions in the Early Endocytic Pathway
2000 • 137 citations
Cloning and Characterization of Phospholipase D from Rat Brain
1997 • 137 citations
Relocalization of Phospholipase D Activity Mediates Membrane Formation During Meiosis
1998 • 137 citations
Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation
1989 • 136 citations
A duplicated catalytic motif in a new superfamily of phosphohydrolases and phospholipid synthases that includes poxvirus envelope proteins
1996 • 135 citations
Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.
1994 • 133 citations
AP-2-containing clathrin coats assemble on mature lysosomes.
1996 • 132 citations
Reversed-phase high performance liquid chromatography of phosphatidylcholine: a simple method for determining relative hydrophobic interaction of various molecular species.
1981 • 131 citations
Functional association between Arf and RalA in active phospholipase D complex
1998 • 131 citations
Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.
1992 • 130 citations
Ca2 +‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation
1987 • 130 citations
Tumor necrosis factor alpha priming of phospholipase D in human neutrophils
1991 • 129 citations
Correlation between secretion and phospholipase D activation in differentiated HL60 cells
1993 • 129 citations
Resolved Phospholipase D Activity Is Modulated by Cytosolic Factors Other than Arf
1995 • 129 citations
Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols
1988 • 128 citations
Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.
1990 • 126 citations
Interaction of the Type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity
2000 • 122 citations
Regulation of Phospholipase D by Protein Kinase C in Human Neutrophils
1995 • 122 citations
Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.
1991 • 120 citations
The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment
1997 • 120 citations
Cardiac Phospholipase D2 Localizes to Sarcolemmal Membranes and Is Inhibited by α-Actinin in an ADP-ribosylation Factor-reversible Manner
2000 • 120 citations
Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13
1998 • 120 citations
Synaptojanin Inhibition of Phospholipase D Activity by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate
1997 • 120 citations
Multiple Sources of 1,2-Diacylglycerol in Isolated Rat Pancreatic Acini Stimulated by Cholecystokinin
1989 • 120 citations
Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells
1996 • 118 citations
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence
1994 • 117 citations
The molecular species composition of individual diacyl phospholipids in human platelets
1982 • 117 citations
Binding of Phosphatidic Acid to the Protein-Tyrosine Phosphatase SHP-1 as a Basis for Activity Modulation
1999 • 117 citations
Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor
1998 • 116 citations
PLD2 Complexes with the EGF Receptor and Undergoes Tyrosine Phosphorylation at a Single Site upon Agonist Stimulation
1998 • 116 citations
Sequential Actions of Phospholipase D and Phosphatidic Acid Phosphohydrolase 2b Generate Diglyceride in Mammalian Cells
1999 • 116 citations
Identification and Characterization of a Novel Plant Phospholipase D That Requires Polyphosphoinositides and Submicromolar Calcium for Activity in Arabidopsis
1997 • 116 citations
The cAMP-specific Phosphodiesterase PDE4D3 Is Regulated by Phosphatidic Acid Binding
2000 • 116 citations
Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells
2000 • 115 citations
Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
1992 • 115 citations
Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells
1995 • 115 citations
Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C.
1988 • 115 citations
Phosphatidic Acid and Diacylglycerol Directly Activate NADPH Oxidase by Interacting with Enzyme Components
2001 • 114 citations
Localization of Phospholipase D in Detergent-insoluble, Caveolin-rich Membrane Domains
1999 • 114 citations
Inhibition of Receptor Signaling to Phospholipase D by Clostridium difficile Toxin B
1996 • 112 citations
Arfaptin 1, a Putative Cytosolic Target Protein of ADP-ribosylation Factor, Is Recruited to Golgi Membranes
1997 • 112 citations
Actin Directly Interacts with Phospholipase D, Inhibiting Its Activity
2001 • 111 citations
Hormonal stimulation of diacylglycerol formation in hepatocytes.
1989 • 111 citations
v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.
1991 • 111 citations
Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.
1990 • 110 citations
An indirect pathway of receptor-mediated 1,2-diacylglycerol formation in mast cells. I. IgE receptor-mediated activation of phospholipase D.
1990 • 109 citations
Distinct Calcium-dependent Pathways of Epidermal Growth Factor Receptor Transactivation and PYK2 Tyrosine Phosphorylation in PC12 Cells
1999 • 109 citations
Expression, Characterization, and Mutagenesis of theYersinia pestis Murine Toxin, a Phospholipase D Superfamily Member
1999 • 108 citations
Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes
1999 • 108 citations
Activation of phospholipase D1 by direct interaction with ADP‐ribosylation factor 1 and RalA
1998 • 108 citations
Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains.
1993 • 107 citations
Role of Phospholipase D Activation in Nervous System Physiology and Pathophysiology
1995 • 107 citations
Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1
1999 • 106 citations
Further studies on the specificity of diacylglycerol for protein kinase C activation
1987 • 106 citations
Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA
1997 • 106 citations
Phospholipase D
1998 • 104 citations
Stimulation of Phosphatidylinositol-4-phosphate 5-Kinase by Rho-Kinase
2000 • 103 citations
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
1990 • 103 citations
Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.
1991 • 102 citations
Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 Exoenzyme
1995 • 102 citations
Phospholipase D Activity Is Required for Actin Stress Fiber Formation in Fibroblasts
2001 • 102 citations
Differential hydrolysis of phospholipid molecular species during activation of human platelets with thrombin and collagen.
1987 • 102 citations
Phosphatidic Acid Is a Potent And Selective Inhibitor of Protein Phosphatase 1 and an Inhibitor of Ceramide-mediated Responses
1999 • 100 citations
Dual Requirement for Rho and Protein Kinase C in Direct Activation of Phospholipase D1 Through G Protein-coupled Receptor Signaling
2000 • 100 citations
Phospholipase D and RalA Cooperate with the Epidermal Growth Factor Receptor To Transform 3Y1 Rat Fibroblasts
2000 • 100 citations
Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C
1991 • 100 citations
Characterization of a Rat Brain Phospholipase D Isozyme
1998 • 99 citations
Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D
1991 • 97 citations
RalA Interacts Directly with the Arf-Responsive, PIP2-Dependent Phospholipase D1
1997 • 97 citations
Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.
1993 • 96 citations
ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells
1995 • 95 citations
Angiotensin II Stimulates Tyrosine Phosphorylation of the Focal Adhesion-associated Protein Paxillin in Aortic Smooth Muscle Cells
1995 • 94 citations
Evidence for ADP‐Ribosylation‐Factor‐Mediated Activation of Phospholipase D by m3 Muscarinic Acetylcholine Receptor
1995 • 94 citations
Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.
1992 • 94 citations
ADP-ribosylation Factor and Rho Proteins Mediate fMLP-dependent Activation of Phospholipase D in Human Neutrophils
1998 • 94 citations
Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors
1994 • 94 citations
Sorting and Signaling at the Golgi Complex
2000 • 94 citations
Different ARF Domains Are Required for the Activation of Cholera Toxin and Phospholipase D
1995 • 93 citations
Selective activation of phospholipase D2 by unsaturated fatty acid
1999 • 92 citations
Structural and chemical specificity of diradylglycerols for protein kinase C activation
1984 • 92 citations
Activation of phospholipase D in a rat mast (RBL 2H3) cell line. A possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release.
1991 • 91 citations
Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester
1992 • 90 citations
Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase.
1995 • 90 citations
Phospholipase D activation in fibroblast membranes by the α and β isoforms of protein kinase C
1994 • 90 citations
Phosphorylation of p22 Is Mediated by Phospholipase D-dependent and -independent Mechanisms
2000 • 88 citations
Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid
1989 • 88 citations
Ras Mediates the Activation of Phospholipase D by v-Src
1995 • 87 citations
The M3 Muscarinic Acetylcholine Receptor Expressed in HEK-293 Cells Signals to Phospholipase D via G12 but Not Gq-type G Proteins
2001 • 87 citations
Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.
1994 • 85 citations
Expression of phospholipase D isoforms in mammalian cells
1999 • 85 citations
Molecular species of lecithins of some functionally distinct rat tissues
1968 • 85 citations
Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes
1997 • 85 citations
ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils
1997 • 84 citations
Up-regulation of phospholipase D activity induced by overexpression of protein kinase C-alpha. Studies in intact Swiss/3T3 cells and in detergent-solubilized membranes in vitro
1993 • 84 citations
The PLD superfamily: insights into catalysis
1999 • 84 citations
Exogenous phospholipase D generates Iysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways
1998 • 84 citations
A Role for Rho-kinase in Rho-controlled Phospholipase D Stimulation by the m3 Muscarinic Acetylcholine Receptor
1999 • 83 citations
Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors
1997 • 83 citations
Phospholipase D1 Is Phosphorylated and Activated by Protein Kinase C in Caveolin-enriched Microdomains within the Plasma Membrane
2000 • 83 citations
Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells.
1994 • 83 citations
The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.
1990 • 82 citations
The α-Subunit of the Heterotrimeric G Protein G13Activates a Phospholipase D Isozyme by a Pathway Requiring Rho Family GTPases
1998 • 81 citations
ARF proteins mediate insulin-dependent activation of phospholipase D
1997 • 81 citations
Separation of Membrane Trafficking and Actin Remodeling Functions of ARF6 with an Effector Domain Mutant
2000 • 81 citations
The Activated Form of the Lck Tyrosine Protein Kinase in Cells Exposed to Hydrogen Peroxide Is Phosphorylated at Both Tyr-394 and Tyr-505
1997 • 80 citations
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.
1994 • 80 citations
Tissue-specific distribution and subcellular distribution of phospholipase D in rat: evidence for distinct RhoA- and ADP-ribosylation factor (ARF)-regulated isoenzymes
1996 • 80 citations
The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils
1984 • 80 citations
Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms
1993 • 78 citations
A Phosphatidic Acid-activated Protein Kinase and Conventional Protein Kinase C Isoforms Phosphorylate p22 , an NADPH Oxidase Component
1999 • 78 citations
Ceramide regulates oxidant release in adherent human neutrophils
1994 • 77 citations
Determination of Interaction Sites on the Small G Protein RhoA for Phospholipase D
1998 • 77 citations
Regulation of Calcium-sensitive Tyrosine Kinase Pyk2 by Angiotensin II in Endothelial Cells
2000 • 76 citations
Identification of a Plasma Membrane-associated Guanine Nucleotide Exchange Factor for ARF6 in Chromaffin Cells
2000 • 76 citations
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes.
1994 • 75 citations
Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C
1991 • 74 citations
Phospholipase D Mediates Matrix Metalloproteinase-9 Secretion in Phorbol Ester-stimulated Human Fibrosarcoma Cells
1999 • 74 citations
A Role for Phospholipase D in GLUT4 Glucose Transporter Translocation
2000 • 73 citations
Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C
1999 • 73 citations
ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells
1996 • 72 citations
Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.
1992 • 72 citations
Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver
1998 • 70 citations
Association of N- and C-terminal Domains of Phospholipase D Is Required for Catalytic Activity
1998 • 69 citations
Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis
2000 • 69 citations
Low Molecular Weight GTP-binding Proteins in HL-60 Granulocytes
1995 • 68 citations
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts
1990 • 68 citations
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils
1990 • 68 citations
Phospholipase D Stimulation by Receptor Tyrosine Kinases Mediated by Protein Kinase C and a Ras/Ral Signaling Cascade
1999 • 68 citations
Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.
1990 • 67 citations
Cholecystokinin Activates PYK2/CAKβ by a Phospholipase C-dependent Mechanism and Its Association with the Mitogen-activated Protein Kinase Signaling Pathway in Pancreatic Acinar Cells
1999 • 67 citations
The Activation of Phospholipase D by Endothelin-1, Angiotensin II, and Platelet-Derived Growth Factor in Vascular Smooth Muscle A10 Cells Is Mediated by Small G Proteins of the ADP-Ribosylation Factor Family*
2000 • 66 citations
fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic free Ca2+ concentration and relation with respiratory burst activation.
1991 • 66 citations
Specific Inhibition of Phorbol Ester-stimulated Phospholipase D by Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B-1470 in HEK-293 Cells
1998 • 65 citations
Regulation of human PLD1 and PLD2 by calcium and protein kinase C
2000 • 65 citations
Inhibition of Phospholipase D Activity by Fodrin
1996 • 65 citations
ADP-ribosylation Factor Proteins Mediate Agonist-induced Activation of Phospholipase D
1998 • 65 citations
Effect of Rho and ADP-ribosylation Factor GTPases on Phospholipase D Activity in Intact Human Adenocarcinoma A549 Cells
1999 • 64 citations
Regulation of phospholipase D by tyrosine kinases
1996 • 64 citations
Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells.
1992 • 63 citations
Association of Phospholipase D Activity with the Detergent-insoluble Cytoskeleton of U937 Promonocytic Leukocytes
1999 • 63 citations
Purification and properties of phospholipase A1 from bovine brain.
1994 • 62 citations
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets
1994 • 62 citations
Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism
1994 • 61 citations
Phospholipase D1 in Caveolae: Regulation by Protein Kinase Cα and Caveolin-1
1999 • 61 citations
The D2s Dopamine Receptor Stimulates Phospholipase D Activity: A Novel Signaling Pathway for Dopamine
2000 • 60 citations
Inhibition of Phospholipase D by Clathrin Assembly Protein 3 (AP3)
1997 • 60 citations
Ral and Rho-Dependent Activation of Phospholipase D in v-Raf-Transformed Cells
1999 • 60 citations
Phospholipase D Activation by Norepinephrine Is Mediated by 12(S)-, 15(S)-, and 20-Hydroxyeicosatetraenoic Acids Generated by Stimulation of Cytosolic Phospholipase A2
2001 • 59 citations
Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes
1989 • 59 citations
Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C.
1988 • 59 citations
Activation of Human Neutrophil NADPH Oxidase by Phosphatidic Acid or Diacylglycerol in a Cell-free System
1999 • 59 citations
ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I
1999 • 58 citations
Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.
1992 • 58 citations
Definition of the Protein Kinase C Interaction Site of Phospholipase D
1998 • 58 citations
Hydrogen Peroxide‐Induced Phospholipase D Activation in Rat Pheochromocytoma PC12 Cells: Possible Involvement of Ca2+‐Dependent Protein Tyrosine Kinase
1997 • 58 citations
Platelet-activating factor-stimulated protein tyrosine phosphorylation and eicosanoid synthesis in rat Kupffer cells. Evidence for calcium-dependent and protein kinase C-dependent and -independent pathways.
1992 • 57 citations
Distribution of ARF6 between Membrane and Cytosol Is Regulated by Its GTPase Cycle
1999 • 56 citations
Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells
1989 • 56 citations
Molecular and biochemical properties and physiological roles of plant phospholipase D
1999 • 56 citations
Fatty Acylation of Phospholipase D1 on Cysteine Residues 240 and 241 Determines Localization on Intracellular Membranes
1999 • 55 citations
Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins
1999 • 55 citations
On the mechanism of enzymatic phosphatidylation. Biosynthesis of cardiolipin catalyzed by phospholipase D
1970 • 54 citations
Association of the N- and C-terminal Domains of Phospholipase D
2000 • 53 citations
Activation of Phospholipase D1 by Cdc42 Requires the Rho Insert Region
2000 • 52 citations
Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN – phosphoinositides as a common denominator?
1997 • 51 citations
Stimulated Mitogen-activated Protein Kinase Is Necessary but Not Sufficient for the Mitogenic Response to Angiotensin II
1996 • 51 citations
Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products.
1990 • 51 citations
ATP-induced potentiation of G-protein-dependent phospholipase D activity in a cell-free system from U937 promonocytic leukocytes.
1993 • 50 citations
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles
1998 • 46 citations
The ADP-ribosylation Factor (ARF)-related GTPase ARF-related Protein Binds to the ARF-specific Guanine Nucleotide Exchange Factor Cytohesin and Inhibits the ARF-dependent Activation of Phospholipase D
1999 • 45 citations
Ethanol inhibits thrombin-induced secretion by human platelets at a site distinct from phospholipase C or protein kinase C
1990 • 45 citations
Regulation and function of PLDs in yeast
1999 • 45 citations
Nuclear ADP-ribosylation Factor (ARF)- and Oleate-dependent Phospholipase D (PLD) in Rat Liver Cells
1997 • 45 citations
Phosphatidylcholine is a quantitatively more important source of increased 1,2-diacylglycerol than is phosphatidylinositol in mast cells.
1990 • 44 citations
Potent Direct Inhibition of Mammalian Phospholipase D Isoenzymes by Calphostin-c
2001 • 44 citations
Involvement of Phosphatidylinositol 3′‐Kinase in Stem‐Cell‐Factor‐Induced Phospholipase D Activation and Arachidonic Acid Release
1997 • 44 citations
Phospholipase D1 is located and activated by protein kinase Cα in the plasma membrane in 3Y1 fibroblast cell
1999 • 43 citations
Phosphatidic Acid Regulates Tyrosine Phosphorylating Activity in Human Neutrophils
2001 • 42 citations
Effects of Activated ADP-ribosylation Factors on Golgi Morphology Require neither Activation of Phospholipase D1 nor Recruitment of Coatomer
2000 • 42 citations
Phospholipase D2: functional interaction with caveolin in low‐density membrane microdomains
2000 • 42 citations
Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.
1991 • 41 citations
Angiotensin II Signaling to Phospholipase D in Renal Microvascular Smooth Muscle Cells in SHR
2001 • 41 citations
Fodrin Inhibits Phospholipases A2, C, and D by Decreasing Polyphosphoinositide Cell Content
1998 • 41 citations
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
2000 • 40 citations
Restoration of Clostridium Difficile Toxin‐B‐Inhibited Phospholipase D by Phosphatidylinositol 4,5‐Bisphosphate
1996 • 40 citations
Effects of cholinergic stimulation on levels and fatty acid composition of diacylglycerols in mouse pancreas
1981 • 40 citations
Sequential activation of heterotrimeric and monomeric G proteins mediates PLD activity in smooth muscle
2001 • 39 citations
Determination of interaction sites of phospholipase D1 for RhoA
2001 • 39 citations
Phospholipid- and GTP-dependent Activation of Cholera Toxin and Phospholipase D by Human ADP-ribosylation Factor-like Protein 1 (HARL1)
1998 • 39 citations
Phospholipase C, Protein Kinase C, Ca2+/Calmodulin‐Dependent Protein Kinase II, and Tyrosine Phosphorylation Are Involved in Carbachol‐Induced Phospholipase D Activation in Chinese Hamster Ovary Cells Expressing Muscarinic Acetylcholine Receptor of Caenorhabditis elegans
2000 • 39 citations
Phospholipase D-induced phosphatidate production in intact small arteries during noradrenaline stimulation: involvement of both G-protein and tyrosine-phosphorylation-linked pathways
1995 • 38 citations
Modification of Catalytically Active Phospholipase D1 with Fatty Acid in Vivo
1999 • 38 citations
Endothelin‐1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase Evidence for involvement in stimulation of mitogenesis
1993 • 36 citations
Muscarinic receptor‐stimulated cytosol‐membrane translocation of RhoA
1997 • 36 citations
Interleukin-11 induces phosphatidic acid formation and activates map kinase in mouse 3T3-L1 cells
1995 • 35 citations
Phospholipase D in rat myometrium: occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins
2000 • 35 citations
A role for protein kinase C‐ϵ in angiotensin II stimulation of phospholipase D in rat renal mesangial cells
1993 • 35 citations
A tyrosine kinase regulates α-adrenoceptor-stimulated contraction and phospholipase D activation in the rat aorta
1996 • 34 citations
Phospholipase D-catalyzed hydrolysis of phosphatidylcholine occurs with PO bond cleavage
1991 • 33 citations
Phosphatidylcholine Turnover in Activated Human Neutrophils.
1995 • 33 citations
Ras/mitogen-activated protein kinase mediates norepinephrine-induced phospholipase D activation in rabbit aortic smooth muscle cells by a phosphorylation-dependent mechanism.
2000 • 33 citations
Selective Stimulation of a CAMP‐Specific Phosphodiesterase (PDE4A5) Isoform by Phosphatidic Acid Molecular Species Endogenously Formed in Rat Thymocytes
1997 • 33 citations
Thrombin induces proliferation of osteoblast-like cells through phosphatidylcholine hydrolysis
1996 • 32 citations
Interleukin-1 and Endothelin Stimulate Distinct Species of Diglycerides That Differentially Regulate Protein Kinase C in Mesangial Cells
1995 • 31 citations
Phospholipase D Is Associated in a Phorbol Ester-Dependent Manner with Protein Kinase C-α and with a 220-kDa Protein Which Is Phosphorylated on Serine and Threonine
1998 • 31 citations
Immunoprecipitation of a Phospholipase D Activity with Antiphosphotyrosine Antibodies
1995 • 30 citations
Distribution of arachidonic acid in choline- and ethanolamine-containing phosphoglycerides in subfractionated human neutrophils
1989 • 30 citations
Effects of Brefeldin A on Phosphatidylcholine Phospholipase D and Inositolphospholipid Metabolism in HL‐60 Cells
1997 • 30 citations
ras‐p21 Activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis Oocytes
1994 • 29 citations
Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein
1990 • 29 citations
Arfaptin 1, an ARF‐binding protein, inhibits phospholipase D and endoplasmic reticulum/Golgi protein transport
1999 • 29 citations
The C Terminus of Mammalian Phospholipase D Is Required for Catalytic Activity
2001 • 28 citations
Thrombin Ca2+-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells
1993 • 28 citations
Characteristics of Protein‐Kinase‐C‐ and ADP‐Ribosylation‐Factor‐Stimulated Phospholipase D Activities in Human Embryonic Kidney Cells
1997 • 27 citations
PKN Regulates Phospholipase D1 through Direct Interaction
2001 • 27 citations
Effects of Arfaptin 1 on Guanine Nucleotide-dependent Activation of Phospholipase D and Cholera Toxin by ADP-ribosylation Factor
1998 • 27 citations
Phospholipase D Activity in L1210 Cells: A Model for Oleate-Activated Phospholipase D in Intact Mammalian Cells
1998 • 27 citations
Conserved amino acids at the C‐terminus of rat phospholipase D1 are essential for enzymatic activity
2000 • 27 citations
Regulation of Phospholipase C-β1 Activity by Phosphatidic Acid
2000 • 27 citations
Overexpression of myristoylated alanine-rich C-kinase substrate enhances activation of phospholipase D by protein kinase C in SK-N-MC human neuroblastoma cells
1998 • 26 citations
Arfaptin 1 forms a complex with ADP‐ribosylation factor and inhibits phospholipase D
1999 • 26 citations
Enhancement of Lysophosphatidic Acid-Induced ERK Phosphorylation by Phospholipase D1 via the Formation of Phosphatidic Acid
2001 • 26 citations
Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.
1992 • 25 citations
Phospholipase D in rat myometrium: occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins
2000 • 25 citations
Identification of Multiple Phosphoinositide-specific Phospholipases D as New Regulatory Enzymes for Phosphatidylinositol 3,4,5-Trisphosphate
1999 • 24 citations
The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts
1995 • 24 citations
Stimulatory Effects of a Short Chain Phosphatidate on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes1
1989 • 24 citations
Multiple Forms of Phospholipase D Inhibitor from Rat Brain Cytosol
1996 • 24 citations
Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification
2001 • 23 citations
G-protein-stimulated Phospholipase D Activity Is Inhibited by Lethal Toxin from Clostridium sordellii in HL-60 Cells
1999 • 23 citations
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase Cγ and protein kinase Cα signalling cascade
2000 • 22 citations
Tyrosine phosphorylation of 100–115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes
1997 • 22 citations
Requirements and Effects of Palmitoylation of Rat PLD1
2001 • 22 citations
Effect ofClostridium difficileToxin B on IgE Receptor-Mediated Signal Transduction in Rat Basophilic Leukemia Cells: Inhibition of Phospholipase D Activation
1996 • 20 citations
Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors.
1994 • 20 citations
Molecular species analysis of 1,2-diacylglycerols and phosphatidic acid formed during bombesin stimulation of Swiss 3T3 cells
1991 • 19 citations
Implication of Ca2+-Dependent Protein Tyrosine Phosphorylation in Carbachol-Induced Phospholipase D Activation in Rat Pheochromocytoma PC12 Cells
1997 • 19 citations
Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities
1999 • 18 citations
Tyrosine kinase is involved in angiotensin II-stimulated phospholipase D activation in aortic smooth muscle cells: Function of Ca2+ influx
1996 • 18 citations
Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor
2000 • 18 citations
Activation of phospholipase D by PKC and GTPγS in human neuroblastoma cells overexpressing MARCKS
2000 • 17 citations
Phospholipase D-dependent and -independent mechanisms are involved in milk protein secretion in rabbit mammary epithelial cells
2000 • 16 citations
The Ang II-Induced Growth of Vascular Smooth Muscle Cells Involves a Phospholipase D-Mediated Signaling Mechanism
2000 • 16 citations
Quantification of contributions of phospholipid precursors to diradylglycerols in stimulated mononuclear phagocytes
1992 • 16 citations
Antigen-mediated phospholipase D activation in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium/calmodulin
1995 • 16 citations
Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes
1999 • 15 citations
Overexpression of Protein Kinase C-ε and Its Regulatory Domains in Fibroblasts Inhibits Phorbol Ester-Induced Phospholipase D Activity
1999 • 15 citations
The roles of protein kinase C and tyrosine kinases in mediating endothelin-1-stimulated phospholipase D activity in rat myometrium: differential inhibition by ceramides and cyclic AMP.
2000 • 14 citations
Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils
1999 • 14 citations
Vasopressin-stimulated Ca2+spiking in vascular smooth muscle cells involves phospholipase D
2001 • 14 citations
Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase
2001 • 14 citations
Diradylglycerol Formation in Cholecystokinin‐Stimulated Rabbit Pancreatic Acini
1996 • 13 citations
Inhibition of phosphatidylinositol 4,5-bisphosphate-stimulated phospholipase D2 activity by Ser/Thr phosphorylation
2000 • 13 citations
Regulation of Early Endosome Fusion by Phospholipase D Activity
1997 • 12 citations
Influence of phosphatidylinositol 4,5-bisphosphate on human phospholipase D1 wild-type and deletion mutants: is there evidence for an interaction of phosphatidylinositol 4,5-bisphosphate with the putative Pleckstrin homology domain?
2000 • 12 citations
Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase
2001 • 12 citations
Low- and High-Affinity Phorbol Ester and Diglyceride Interactions with Protein Kinase C: 1-O-Alkyl-2-acyl-sn-glycerol Enhances Phorbol Ester- and Diacylglycerol-Induced Activity but Alone Does Not Induce Activity
2001 • 11 citations
Expression of a peptide binding to receptor for activated C-kinase (RACK1) inhibits phorbol myristoyl acetate-stimulated phospholipase D activity in C3H/10T1/2 cells: dissociation of phospholipase D-mediated phosphatidylcholine breakdown from its synthesis
2000 • 10 citations
GTP-binding protein-stimulated phospholipase C and phospholipase D activities in ras-transformed NIH 3T3 fibroblasts.
1990 • 9 citations
Enzymatic Characterization of Phospholipase D of Protozoan Tetrahymena Cells
2001 • 8 citations
The activation of phospholipase D participates in the mitogenic action of arginine vasopressin in cultured rat glomerular mesangial cells.
1996 • 8 citations
Low molecular weight GTP-binding proteins in hepatocytes and an assessment of the role of p21ras proteins in the activation of phospholipase D.
1991 • 3 citations