Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes

1988 • 963 citations

The respiratory burst of phagocytes.

1984 • 914 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.

1980 • 408 citations

Oxidant-induced DNA damage of target cells.

1988 • 382 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.

1985 • 300 citations

Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

1986 • 294 citations

The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

1985 • 282 citations

Protein kinase C and the activation of the human neutrophil NADPH- oxidase

1987 • 268 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Chemoattractant Receptors on Phagocytic Cells

1984 • 236 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells.

1987 • 232 citations

Structure of the lipid moiety of the Leishmania donovani lipophosphoglycan.

1987 • 228 citations

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.

1986 • 215 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

Studies on the Structure of Glyceryl Ethers and the Glyceryl Ether Phospholipids of Bovine Erythrocytes^*

1963 • 182 citations

1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

1984 • 173 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

The Enzymic Synthesis of Ethanolamine Plasmalogens

1971 • 157 citations

Secretagogue-induced phosphoinositide metabolism in human leucocytes

1984 • 152 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Surface‐reactive stimuli selectively increase protein phosphorylation in human neutrophils

1981 • 134 citations

Cytochalasin B enhancement of the diacylglycerol response in formyl peptide-stimulated neutrophils.

1986 • 133 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols

1988 • 128 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.

1988 • 119 citations

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

1982 • 116 citations

Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils.

1987 • 103 citations

Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.

1988 • 101 citations

The protein kinase C inhibitors H-7 and H-9 fail to inhibit human neutrophil activation

1986 • 95 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

Structural and chemical specificity of diradylglycerols for protein kinase C activation

1984 • 92 citations

Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe.

1988 • 91 citations

Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate

1987 • 86 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis.

1985 • 84 citations

Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.

1988 • 79 citations

Complete dissociation between the activation of phosphoinositide turnover and of NADPH oxidase by formyl-methionyl-leucyl-phenylalanine in human neutrophils depleted of Ca2+ and primed by subthreshold doses of phorbol 12,myristate 13,acetate

1986 • 79 citations

Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1986 • 73 citations

Phosphorylation of cytosolic proteins by resting and activated human neutrophils

1984 • 69 citations

1-O-hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells

1984 • 65 citations

Alkyl analogs of diacylglycerol as activators of protein kinase C

1987 • 61 citations

Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C.

1988 • 59 citations

Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe

1986 • 46 citations

Alkylacylglycerol molecular species in the glycosylinositol phospholipid membrane anchor of bovine erythrocyte acetylcholinesterase

1988 • 46 citations

Parallel changes in amino acid transport and protein kinase C localization in LLC‐PK₁ cells treated with TPA or diradylglycerols

1987 • 40 citations

A new class of antihypertensive neutral lipid: 1-Alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor

1984 • 36 citations

Ether-phospholipid composition in neutrophile and platelets

1985 • 25 citations

Multiple modes of protein kinase C regulation and their significance in signalling

1988 • 24 citations

Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant‐activated human polymorphonuclear leukocytes

1987 • 22 citations

Immunocytochemical localization of protein kinase C in resting and activated human neutrophils

1987 • 21 citations

Deleted Work

1955 • 0 citations