Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

Endothelin, a novel endothelium-derived peptide

1989 • 365 citations

Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain

1988 • 362 citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

1989 • 353 citations

Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

1989 • 346 citations

Molecular mechanism of action of the vasoconstrictor peptide endothelin

1988 • 317 citations

Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?

1989 • 299 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells

1989 • 230 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

Development of a novel, Ins(1,4,5)P3-specific binding assay: Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes

1989 • 182 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

1989 • 176 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes

1988 • 163 citations

The phosphatidylcholine pathway of diacylglycerol formation stimulated by phorbol diesters occurs via phospholipase D activation

1988 • 156 citations

Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols

1989 • 154 citations

Endothelin-mediated stimulation of DNA synthesis in vascular smooth muscle cells

1989 • 147 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Three apparent receptor subtypes for the endothelin/sarafotoxin family

1989 • 110 citations

Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors

1989 • 98 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts

1990 • 67 citations

Retraction

1991 • 60 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Phorbol ester promotes a sustained down-regulation of endothelin receptors and cellular responses to endothelin in human vascular smooth muscle cells

1990 • 41 citations

G-proteins and second messengers in mitogenesis

1989 • 3 citations