ADP-ribosylation Factor and Rho Proteins Mediate fMLP-dependent Activation of Phospholipase D in Human Neutrophils

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

The Dbl family of oncogenes

1996 • 497 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

1996 • 465 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D

1997 • 390 citations

New Developments in Phospholipase D

1997 • 313 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Myristoylation of ADP-ribosylation Factor 1 Facilitates Nucleotide Exchange at Physiological Mg 2+ Levels

1995 • 185 citations

Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells

1989 • 183 citations

Role of Protein-Phospholipid Interactions in the Activation of ARF1 by the Guanine Nucleotide Exchange Factor Arno

1997 • 169 citations

Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex

1993 • 158 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

1996 • 149 citations

Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor

1997 • 148 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

1995 • 143 citations

Correlation between secretion and phospholipase D activation in differentiated HL60 cells

1993 • 129 citations

Resolved Phospholipase D Activity Is Modulated by Cytosolic Factors Other than Arf

1995 • 129 citations

The Myristoylated Amino Terminus of ADP-ribosylation Factor 1 Is a Phospholipid- and GTP-sensitive Switch

1995 • 127 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

Cloning and expression analysis of murine phospholipase D1

1997 • 115 citations

Inhibition of Receptor Signaling to Phospholipase D by Clostridium difficile Toxin B

1996 • 112 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells

1992 • 104 citations

Diacylglycerol accumulation and superoxide anion production in stimulated human neutrophils.

1987 • 103 citations

ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin‐sensitive guanine nucleotide‐binding protein coupled to phospholipase C

1989 • 102 citations

Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 Exoenzyme

1995 • 102 citations

ADP-ribosylation Factor Functions Synergistically with a 50-kDa Cytosolic Factor in Cell-free Activation of Human Neutrophil Phospholipase D

1995 • 101 citations

Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes

1997 • 90 citations

Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.

1994 • 85 citations

ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils

1997 • 84 citations

ARF proteins mediate insulin-dependent activation of phospholipase D

1997 • 81 citations

Use of cytochalasin B to distinguish between early and late events in neutrophil activation

1980 • 80 citations

Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

1994 • 80 citations

The role of polyphosphoinositides and their breakdown products in A23187-induced release of arachidonic acid from rabbit polymorphonuclear leucocytes

1986 • 79 citations

Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells.

1991 • 73 citations

ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells

1996 • 72 citations

RhoA and a Cytosolic 50-kDa Factor Reconstitute GTPγS-dependent Phospholipase D Activity in Human Neutrophil Subcellular Fractions

1995 • 70 citations

Low Molecular Weight GTP-binding Proteins in HL-60 Granulocytes

1995 • 68 citations

Phospholipase D: Regulation by GTPases and protein kinase C and physiological relevance

1996 • 59 citations

GTP but not GDP analogues promote association of ADP-ribosylation factors, 20-kDa protein activators of cholera toxin, with phospholipids and PC-12 cell membranes.

1992 • 56 citations

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase γ in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils

1997 • 56 citations

Redistribution of ADP-ribosylation factor during stimulation of permeabilized cells with GTP analogues

1991 • 55 citations

Features of the translocation of protein kinase C in neutrophils stimulated with the chemotactic peptide f-Met-Leu-Phe

1986 • 46 citations

Activation of Phospholipase D and Phosphatidylinositol 4-Phosphate 5-Kinase in HL60 Membranes Is Mediated by Endogenous Arf but Not Rho

1996 • 46 citations

Rat brain cytosol contains a factor which reconstitutes guanine‐nucleotide‐binding‐protein‐regulated phospholipase‐D activation in HL60 cells previously permeabilized with streptolysin O

1993 • 41 citations

Calcium rather than protein kinase C is the major factor to activate phospholipase D in FMLP-stimulated rabbit peritoneal neutrophils. Possible involvement of calmodulin/myosin L chain kinase pathway.

1992 • 40 citations

Effect of wortmannin and 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 Cells

1997 • 31 citations