Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

1998 • 774 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes

1998 • 624 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

1999 • 513 citations

Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains

1998 • 497 citations

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

1996 • 465 citations

Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

1994 • 418 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Generation of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes

1998 • 345 citations

New Developments in Phospholipase D

1997 • 313 citations

Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors

1999 • 293 citations

A Role for Giantin in Docking COPI Vesicles to Golgi Membranes

1998 • 284 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Essential role for diacylglycerol in protein transport from the yeast Golgi complex

1997 • 257 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase

1997 • 224 citations

Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone

1993 • 210 citations

Phospholipase D signaling is essential for meiosis.

1995 • 208 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes

1998 • 200 citations

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

1998 • 200 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

A role for phosphatidylinositol transfer protein in secretory vesicle formation

1995 • 186 citations

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

1997 • 174 citations

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes

1994 • 169 citations

Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

1998 • 161 citations

Distinct Roles for the p110α and hVPS34 Phosphatidylinositol 3′-Kinases in Vesicular Trafficking, Regulation of the Actin Cytoskeleton, and Mitogenesis

1998 • 150 citations

Reassembly of Golgi stacks from mitotic Golgi fragments in a cell-free system.

1995 • 139 citations

A Role for Phospholipase D (Pld1p) in Growth, Secretion, and Regulation of Membrane Lipid Synthesis in Yeast

1998 • 138 citations

Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels

1998 • 138 citations

Evidence that phospholipase A ₂ activity is required for Golgi complex and trans Golgi network membrane tubulation

1998 • 136 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate

1998 • 128 citations

Lipid regulators of membrane traffic through the Golgi complex

1999 • 127 citations

ADP ribosylation factor regulates spectrin binding to the Golgi complex

1998 • 126 citations

COP-coated vesicles are involved in the mitotic fragmentation of Golgi stacks in a cell-free system.

1994 • 122 citations

Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells

1995 • 115 citations

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

1993 • 112 citations

Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes

1999 • 108 citations

The organisation of the Golgi apparatus

1998 • 106 citations

ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function

1998 • 97 citations

Functional Interaction of ADP-ribosylation Factor 1 with Phosphatidylinositol 4,5-Bisphosphate

1997 • 91 citations

An essential role for a protein and lipid kinase complex in secretory protein sorting

1992 • 86 citations

Intracellular translocation and metabolism of a fluorescent phosphatidic acid analogue in cultured fibroblasts.

1983 • 82 citations

Phosphatidylinositol transfer proteins: the long and winding road to physiological function

1998 • 79 citations

The involvement of the Golgi apparatus in the pathogenesis of amyotrophic lateral sclerosis, Alzheimer's disease, and ricin intoxication

1998 • 73 citations

Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.

1996 • 68 citations

Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN – phosphoinositides as a common denominator?

1997 • 51 citations

Somatostatin discriminates between the intracellular pathways of secretory and membrane proteins.

1984 • 50 citations

ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles

1998 • 46 citations

Microinjection of mRNA coding for an anti-golgi antibody inhibits intracellular transport of a viral membrane protein

1984 • 41 citations

Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complex

1998 • 40 citations

Disease models provide insights into post-Golgi protein trafficking, localization and processing

1999 • 23 citations

Heterologous expression of preprosomatostatin. Intracellular degradation of prosomatostatin-II

1991 • 15 citations

Calphostin C induces selective disassembly of the Golgi complex by a protein kinase C-independent mechanism

1998 • 12 citations

Signal Transduction Protocols

1995 • 5 citations