Selective Stimulation of a CAMP‐Specific Phosphodiesterase (PDE4A5) Isoform by Phosphatidic Acid Molecular Species Endogenously Formed in Rat Thymocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Commission on Biochemical Nomenclature

1987 • 431 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

The Nomenclature of Lipids. Recommendations, 1976

1977 • 285 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Multiple isozymes of cyclic nucleotide phosphodiesterase.

1988 • 239 citations

The nomenclature of lipids (Recommendations 1976) IUPAC-IUB Commission on Biochemical Nomenclature

1978 • 225 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

[30] Assay of cyclic nucleotide phosphodiesterases with radioactive substrates

1974 • 184 citations

Messenger functions of phosphatidic acid

1996 • 177 citations

Multiple isozymes of cyclic nucleotide phosphodiesterase.

1988 • 162 citations

Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells

1995 • 145 citations

A Sensitive Method for Quantitative Analysis of Phospholipid Molecular Species by High-Performance Liquid Chromatography

1985 • 136 citations

Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.

1988 • 129 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

3′, 5′-Cyclic nucleotide phosphodiesterase

2001 • 108 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

1988 • 97 citations

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram

1996 • 80 citations

Selective Activation of Rolipram-Sensitive, cAMP-Specific Phosphodiesterase Isoforms by Phosphatidic Acid

1997 • 63 citations

Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by coomassie blue staining and densitometry

1989 • 56 citations

Cyclic AMP‐mediated alteration of the CD2 activation process in human T lymphocytes. Preferential inhibition of the phosphoinositide cycle‐related transduction pathway

1988 • 53 citations

Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.

1993 • 48 citations

Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.

1984 • 46 citations

Cell signalling through phospholipid breakdown

1991 • 45 citations

Transmembrane signals in the activation of T-lymphocytes by lectin mitogens

1988 • 42 citations

Identification of cyclic AMP‐phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

1996 • 40 citations

Concanavalin A stimulates the rolipram-sensitive isoforms of cyclic nucleotide phosphodiesterase in rat thymic lymphocytes

1990 • 39 citations

Activation of cyclic nucleotide phosphodiesterases in FRTL-5 thyroid cells expressing a constitutively active Gs alpha.

1995 • 37 citations

Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes

1993 • 34 citations

High pressure liquid chromatography of cyclic nucleotide phosphodiesterase from purified human T-lymphocytes

1989 • 32 citations

A Highly Sensitive Method for Quantitative Analysis of Phospholipid Molecular Species by High-Performance Liquid Chromatography1

1991 • 32 citations

Anthracene-9-carbonyl chloride as a fluorescene and ultraviolet derivatising reagent for the high-performance liquid chromatographic analysis of hydroxy compounds

1988 • 30 citations

Early increase in lymphocyte cyclic nucleotide phosphodiesterase activity upon mitogenic activation of human peripheral blood mononuclear cells

1992 • 27 citations

Suppression of human lymphocyte responsiveness by forskolin: reversal by 12-O-tetradecanoyl phorbol 13-acetate, diacylglycerol and ionomycin

1987 • 26 citations

Cyclic nucleotide phosphodiesterase from a particulate fraction of rat heart. Solubilization and characterization of a single enzymatic form

1981 • 25 citations

Interleukin-1 stimulates phosphatidic acid-mediated phospholipase D activity in human mesangial cells

1994 • 24 citations

Time-course changes in content and fatty acid composition of phosphatidic acid from rat thymocytes during concanavalin A stimulation

1995 • 19 citations

Activation of a cyclic nucleotide phosphodiesterase 4 (PDE4) from rat thymocytes by phosphatidic acid

1996 • 17 citations

Evaluation of methods for the isolation of plasma membranes displaying guanosine 5′-triphosphate-dependence for the regulation of adenylate cyclase activity: Potential application to the study of other guanosine 5′-triphosphate-dependent transduction systems

1988 • 16 citations

Contribution of phosphoinositides and phosphatidylcholines to the production of phosphatidic acid upon concanavalin A stimulation of rat thymocytes

1996 • 14 citations

Activation of cyclic nucleotide phosphodiesterases in FRTL-5 thyroid cells expressing a constitutively active Gs alpha

1995 • 9 citations