Interleukin-11 induces phosphatidic acid formation and activates map kinase in mouse 3T3-L1 cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Cytokine regulation of neuronal differentiation of hippocampal progenitor cells

1993 • 307 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications

1993 • 274 citations

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

1993 • 267 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.

1990 • 175 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts.

1992 • 164 citations

Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells

1984 • 159 citations

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

1991 • 156 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.

1992 • 147 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Activation of NADPH-dependent superoxide production in plasma membrane extracts of pig neutrophils by phosphatidic acid.

1988 • 138 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells.

1989 • 128 citations

Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?

1991 • 124 citations

Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system.

1992 • 101 citations

Interleukin-11 stimulates multiple phases of erythropoiesis in vitro

1992 • 95 citations

Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.

1984 • 90 citations

Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.

1993 • 88 citations

Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases.

1992 • 78 citations

Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells.

1992 • 69 citations

Stimulation of quiescent 3T3 cells by phosphatidic acid-containing liposomes

1987 • 58 citations

Possible Involvement of Normal p21 H-ras in the Insulin/Insulinlike Growth Factor 1 Signal Transduction Pathway

1989 • 52 citations

Postreceptor events associated with human neutrophil activation by interleukin-8

1992 • 50 citations

Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases

1992 • 46 citations

Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase

1992 • 44 citations

Interleukin-11 and its receptor.

1992 • 39 citations

New pathways of phagocyte activation: the coupling of receptor-linked phospholipase D and the role of tyrosine kinase in primed neutrophils

1992 • 29 citations

Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.

1989 • 28 citations

Interleukins 9, 10, 11 and 12 and kit ligand: A brief overview

1992 • 28 citations

Regulation of interleukin‐2 responses by phosphatidic acid

1992 • 27 citations

Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.

1992 • 25 citations

Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells

1992 • 21 citations

Membrane‐Associated Phospholipase D Activity in Rat Sciatic Nerve

1991 • 18 citations

IL-3-induced generation of alkylacylglycerol and diacylglycerol in an IL-3-dependent cell line.

1991 • 14 citations

GTP binding proteins and growth factor signal transduction

1991 • 13 citations

Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells

1991 • 12 citations

Oligomer formation of staphylococcal α-toxin analyzed by electron microscopy and image processing

1992 • 9 citations