Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Transphosphatidylation by Phospholipase D

1967 • 563 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

The insulin-mimetic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+)ATPase inhibitor.

1980 • 392 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Phospholipase D

1978 • 190 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 • 168 citations

Receptor regulation of choline phospholipid hydrolysis

1989 • 167 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells.

1992 • 145 citations

Tyrosine phosphorylation in human neutrophil

1989 • 140 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells.

1989 • 118 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Platelet-activating factor induces tyrosine phosphorylation in human neutrophils.

1991 • 106 citations

Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells

1992 • 104 citations

Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils

1989 • 101 citations

Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.

1990 • 101 citations

A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.

1990 • 100 citations

Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization

1991 • 98 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Phosphatidylethanol formation in human platelets: Evidence for thrombin-induced activation of phospholipase D

1988 • 88 citations

Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.

1991 • 87 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Regulation of phospholipase D and primary granule secretion by P2-purinergic- and chemotactic peptide-receptor agonists is induced during granulocytic differentiation of HL-60 cells.

1991 • 73 citations

Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.

1992 • 72 citations

Protein tyrosine phosphorylation in rabbit peritoneal neutrophils

1990 • 68 citations

Phospholipase D activation by the mitogens platelet‐derived growth factor and 12‐O‐tetradecanoylphorbol 13‐acetate in NIH‐3T3 cells

1989 • 64 citations

Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes

1991 • 62 citations

Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

1991 • 62 citations

A novel mechanism for acetylcholine to generate diacylglycerol in brain.

1990 • 50 citations

Pertussis toxin produces differential inhibitory effects on basal, P2-purinergic, and chemotactic peptide-stimulated inositol phospholipid breakdown in HL-60 cells and HL-60 cell membranes.

1990 • 45 citations

Long-term phorbol ester treatment dissociates phospholipase D activation from phosphoinositide hydrolysis and prostacyclin synthesis in endothelial cells stimulated with bradykinin

1989 • 35 citations

Guanine Nucleotide‐Binding Protein Regulation of Microsomal Phospholipase D Activity of Canine Cerebral Cortex

1990 • 33 citations

Phosphatidylcholine hydrolysis stimulated by phorbol myristate acetate is mediated principally by phospholipase D in endothelial cells

1990 • 28 citations

Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells

1991 • 18 citations