Phospholipase D Activity Is Required for Actin Stress Fiber Formation in Fibroblasts

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Rho GTPases

1998 • 534 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Phospholipase D: molecular and cell biology of a novel gene family

2000 • 495 citations

The structure and function of α-actinin

1989 • 421 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Regulation of phospholipase D

1999 • 369 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors

1999 • 293 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Phosphorylation of Vimentin by Rho-associated Kinase at a Unique Amino-terminal Site That Is Specifically Phosphorylated during Cytokinesis

1998 • 222 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

1996 • 215 citations

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes

1998 • 200 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

1997 • 174 citations

Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes

1999 • 174 citations

Structural Analysis of Human Phospholipase D1

1999 • 169 citations

Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface

1999 • 165 citations

Molecular Analysis of Mammalian Phospholipase D2

1999 • 157 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Diacylglycerol in large α-actinin/actin complexes and in the cytoskeleton of activated platelets

1985 • 147 citations

Localization and possible functions of phospholipase D isozymes

1999 • 145 citations

Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels

1998 • 138 citations

Identification of a Phosphatidylinositol 4,5-Bisphosphate-binding Site in Chicken Skeletal Muscle α-Actinin

1996 • 123 citations

Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1

1999 • 106 citations

A novel protein kinase target for the lipid second messenger phosphatidic acid

1999 • 97 citations

Regulation of phospholipase D by phosphorylation-dependent mechanisms

1999 • 86 citations

Actin binding proteins — lipid interactions

1991 • 86 citations

Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

1997 • 83 citations

Phospholipase D Mediates Matrix Metalloproteinase-9 Secretion in Phorbol Ester-stimulated Human Fibrosarcoma Cells

1999 • 74 citations

Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C

1999 • 73 citations

Association of N- and C-terminal Domains of Phospholipase D Is Required for Catalytic Activity

1998 • 69 citations

Association of Phospholipase D Activity with the Detergent-insoluble Cytoskeleton of U937 Promonocytic Leukocytes

1999 • 63 citations

Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism

1994 • 61 citations

Definition of the Protein Kinase C Interaction Site of Phospholipase D

1998 • 58 citations

Association of the N- and C-terminal Domains of Phospholipase D

2000 • 53 citations

Structure and Assembly

1995 • 47 citations

Stimulus-Induced Selective Association of Actin-Associated Proteins (α-Actinin) and Protein Kinase C Isoforms with the Cytoskeleton of Human Neutrophils

1999 • 37 citations

Phospholipase D Is Associated in a Phorbol Ester-Dependent Manner with Protein Kinase C-α and with a 220-kDa Protein Which Is Phosphorylated on Serine and Threonine

1998 • 31 citations

Conserved amino acids at the C‐terminus of rat phospholipase D1 are essential for enzymatic activity

2000 • 27 citations