Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

1975 • 749 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Eosinophils as mediators of antibody-dependent damage to schistosomula

1975 • 369 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.

1981 • 367 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.

1991 • 241 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

1992 • 163 citations

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.

1990 • 158 citations

An Improved Method for the Isolation of Eosinophilic Granulocytes From Peripheral Blood of Normal Individuals

1988 • 151 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Isolation of human eosinophil phospholipase D.

1976 • 139 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.

1991 • 115 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Modulation of rat brain cytosolic phosphatidate phosphohydrolase: Effect of cationic amphiphilic drugs and divalent cations

1987 • 103 citations

Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni.

1987 • 87 citations

Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

1990 • 78 citations

Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies.

1995 • 69 citations

Fc gamma R-mediated killing by eosinophils.

1989 • 67 citations

fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic free Ca2+ concentration and relation with respiratory burst activation.

1991 • 66 citations

Priming of the respiratory burst in human eosinophils is accompanied by changes in signal transduction.

1990 • 59 citations

Divergent effects of propranolol on neutrophil superoxide release: Involvement of phosphatidic acid and diacylglycerol as second messengers

1991 • 49 citations

Cooperation between Fc gamma receptor II and complement receptor type 3 during activation of platelet-activating factor release by cytokine-primed human eosinophils.

1994 • 42 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3

1994 • 41 citations

Eosinophils isolated with two different methods show different characteristics of activation

1995 • 38 citations

Purification of eosinophils from normal human blood, preparation of eosinoplasts and characterization of their functional response to various stimuli.

1987 • 37 citations

Effects of Ethanol on the Chemotactic Peptide-Induced Second Messenger Generation and Superoxide Production in Polymorphonuclear Leukocytes

1992 • 34 citations

Priming of human eosinophils by platelet-activating factor enhances the number of cells able to bind and respond to opsonized particles.

1992 • 30 citations

The chymotrypsin inhibitor carbobenzyloxy-leucine-tyrosine-chloromethylketone interferes with phospholipase D activation induced by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1991 • 30 citations

Activation of phospholipase D in normodense human eosinophils

1990 • 26 citations

Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles

1992 • 24 citations

Activation of the β2 integrin Mac-1 (CD11b/CD18) by an endogenous lipid mediator of human neutrophils and HL-60 cells

1997 • 14 citations

A Leukocyte Lipid Up-Regulates the Avidity of Lymphocyte Function-Associated Antigen-1

1994 • 11 citations