Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Protein kinase C

1991 • 914 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

Effect of phorbol esters on protein kinase C-zeta.

1992 • 282 citations

Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.

1988 • 270 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1986 • 217 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Purification and characterisation of bovine brain protein kinase C isotypes α, β and γ

1989 • 169 citations

Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 • 168 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

ARF signaling: A potential role for phospholipase D in membrane traffic

1993 • 161 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Cloning, expression and chromosomal localization of a new putative receptor‐like protein tyrosine phosphatase

1991 • 134 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo

1992 • 121 citations

Phospholipid Functional Groups Involved in Protein Kinase C Activation, Phorbol Ester Binding, and Binding to Mixed Micelles

1989 • 115 citations

Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

1993 • 112 citations

Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains.

1993 • 107 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.

1993 • 106 citations

A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes.

1990 • 98 citations

Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding

1992 • 94 citations

Protein kinase Cζ and n in murine epidermis TPA induces down‐regulation of PKCn but not PKCζ

1992 • 88 citations

Detection of the myristylated gag-raf transforming protein with raf-specific antipeptide sera

1985 • 87 citations

Protein kinase C autophosphorylates by an intrapeptide reaction.

1987 • 83 citations

Purification and characterization of protein kinase C .epsilon. from rabbit brain

1992 • 77 citations

Activation of Protein Kinase C by Phosphatidylinositol 3,4,5-Trisphosphate

1993 • 76 citations

Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function

1990 • 75 citations

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε

1993 • 70 citations

Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid.

1993 • 68 citations

The phosphorylation of protein kinase C as a potential measure of activation

1989 • 68 citations

Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation

1990 • 67 citations

Phospholipids containing polyunsaturated fatty acyl groups are mitogenic for normal mouse mammary epithelial cells in serum-free primary cell culture.

1989 • 62 citations

Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production.

1992 • 58 citations

Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner.

1994 • 57 citations

The regulatory domain of protein kinase C-ε restricts the catalytic-domain-specificity

1991 • 53 citations

Protein kinase C

1992 • 53 citations

Activation of purified human protein kinase C α and β I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate

1993 • 39 citations

Transbilayer movement and metabolic fate of ether-linked phosphatidic acid (1-O-Octadecyl-2-acetyl-sn-glycerol 3-phosphate) in guinea pig peritoneal polymorphonuclear leukocytes.

1992 • 26 citations

Lipid vesicles which can bind to protein kinase C and activate the enzyme in the presence of EGTA

1992 • 25 citations

Muscarinic stimulation of SK-N-BE(2) human neuroblastoma cells elicits phosphoinositide and phosphatidylcholine hydrolysis: relationship to diacylglycerol and phosphatidic acid accumulation

1993 • 21 citations

Characterization of endogenous substrates for novel-type protein kinase C as well as conventional-type protein kinase C in primary cultured mouse epidermal cells

1992 • 9 citations

Cited By (0)

Loading...