Regulation of phospholipase D by tyrosine kinases

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The MAPK signaling cascade

1995 • 3,300 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Handbook of lipid research

1978 • 978 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Phospholipids and cellular regulation

1985 • 331 citations

Regulation of the transcription factors NF-κB and AP-1 by redox changes

1994 • 310 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

1986 • 229 citations

Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis

1984 • 228 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Platelet‐activating factor receptor and signal transduction mechanisms ¹

1992 • 197 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Phospholipase D

1978 • 190 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor

1995 • 187 citations

Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L.

1994 • 185 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Formation of phosphatidylethanol in rat brain by phospholipase D

1987 • 170 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

1990 • 163 citations

ARF signaling: A potential role for phospholipase D in membrane traffic

1993 • 161 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Phospholipase D and cell signaling

1993 • 161 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

Partial purification and properties of a rat brain phospholipase.

1979 • 149 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Purification and characterization of phosphatidylcholine phospholipase D from pig lung.

1994 • 137 citations

A role for phospholipase D in control of mitoqenesis

1994 • 137 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Signal-activated phospholipases

1994 • 134 citations

Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates

1993 • 132 citations

Regulation of Phospholipase D by Protein Kinase C in Human Neutrophils

1995 • 122 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells

1996 • 118 citations

v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.

1991 • 111 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

Phosphatidohydrolase activity in a solubilized preparation from rat brain particulate fraction

1975 • 108 citations

ON THE NATURE OF THE PHOSPHORUS-CONTAINING LIPIDES OF CABBAGE LEAVES AND THEIR RELATION TO A PHOSPHOLIPIDE-SPLITTING ENZYME CONTAINED IN THESE LEAVES

1948 • 107 citations

A combination of hydrogen peroxide and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines

1990 • 106 citations

ADP-ribosylation Factor Functions Synergistically with a 50-kDa Cytosolic Factor in Cell-free Activation of Human Neutrophil Phospholipase D

1995 • 101 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.

1992 • 94 citations

Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors

1994 • 94 citations

Purification and Immunological Analysis of Phospholipase D from Castor Bean Endosperm

1993 • 93 citations

Oxidized low density lipoprotein-mediated activation of phospholipase D in smooth muscle cells: a possible role in cell proliferation and atherogenesis.

1995 • 89 citations

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid

1989 • 88 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Stimulation of choline release from NG108-15 cells by 12-O-tetradecanoylphorbol 13-acetate

1987 • 86 citations

Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.

1994 • 85 citations

Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells.

1994 • 83 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

The Phospholipases

1987 • 79 citations

Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms

1993 • 78 citations

Protein kinase C involvement in lipid peroxidation and cell membrane damage induced by oxygen-based radicals in hepatocytes

1989 • 77 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis

1990 • 73 citations

Activation of Protein Phosphorylation by Oxidants in Vascular Endothelial Cells: Identification of Tyrosine Phosphorylation of Caveolin

1997 • 71 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

Oxidants and signal transduction in vascular endothelium.

1995 • 70 citations

v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters

1993 • 60 citations

Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells

1989 • 56 citations

Improved purification and biochemical characterization of phospholipase D from cabbage

1993 • 55 citations

Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils

1993 • 55 citations

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

1991 • 53 citations

Hydrogen Peroxide Regulates Phospholipase D-Mediated Hydrolysis of Phosphatidylethanolamine and Phosphatidylcholine by Different Mechanisms in NIH 3T3 Fibroblasts

1994 • 52 citations

Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.

1994 • 51 citations

Pancreas growth, tyrosine kinase, PtdIns 3-kinase, and PLD involve high-affinity CCK-receptor occupation

1994 • 49 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases

1992 • 46 citations

Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-α in normal human skin fibroblasts and keratinocytes

1993 • 44 citations

5-Hydroxyicosatetraenoate promotes Ca2+ and protein kinase C mobilization in neutrophils

1987 • 43 citations

Messenger molecules derived from membrane lipids

1994 • 42 citations

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.

1993 • 41 citations

Phospholipase D-induced phosphatidate production in intact small arteries during noradrenaline stimulation: involvement of both G-protein and tyrosine-phosphorylation-linked pathways

1995 • 38 citations

Phosphatase Inhibitors Potentiate 4-Hydroxynonenal-induced Phospholipase D Activation in Vascular Endothelial Cells

1997 • 38 citations

Differential effects of platelet-derived growth factor, serum and bombesin on phospholipase D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts

1992 • 38 citations

Endothelin‐1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase Evidence for involvement in stimulation of mitogenesis

1993 • 36 citations

Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes

1993 • 34 citations

ARF1‐regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP

1994 • 34 citations

Temporal regulation of the IgE-dependent 1,2-diacylglycerol production by tyrosine kinase activation in a rat (RBL 2H3) mast-cell line

1994 • 31 citations

Effects of Phosphatidic Acid on Islet Cell Phosphoinositide Hydrolysis, Ca2+, and Adenylate Cyclase

1989 • 30 citations

Alcohols selectively stimulate phospholipase D‐mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 cells

1989 • 30 citations

Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D.

1993 • 30 citations

Epinephrine induces association of pp60src with Giα in human platelets

1992 • 29 citations

Regulation of interleukin‐2 responses by phosphatidic acid

1992 • 27 citations

Lysophosphatidic Acid: A Novel Phospholipid with Hormone- and Growth Factor-like Activities

1992 • 26 citations

Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.

1992 • 25 citations

The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts

1995 • 24 citations

Dissociation of inositol trisphosphate from diacylglycerol production in Rous sarcoma virus-transformed fibroblasts.

1989 • 24 citations

Phosphatidate-induced arachidonic acid mobilization in mouse peritoneal macrophages.

1994 • 23 citations

NF-κB Transcription Factor Activation by Hydrogen Peroxide Can Be Decreased by 2,3-Dihydroxybenzoic Acid and Its Ethyl Ester Derivative

1995 • 22 citations

Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors.

1994 • 20 citations

The protein tyrosine kinase pp60c-src is activated upon platelet stimulation.

1994 • 19 citations

Calcium-Independent Activation of Protein Kinase C by the Dianionic Form of Phosphatidic Acid

1993 • 17 citations

Tyrosine kinase regulates phospholipase D activation at a point downstream from protein kinase C in osteoblast‐like cells

1995 • 16 citations

Novel model of integration of signaling pathways in rat pancreatic acinar cells

1995 • 16 citations

Ethanolamine is released from glial cells in primary culture on stimulation with foetal calf serum and phorbol ester

1992 • 15 citations

Phospholipase D activity in nontransformed and transformed fibroblasts

1992 • 11 citations

Defective Phospholipase D Activation in Ki-ras-Transformed NIH3T3 Cells: Evidence for Downstream Effector of Plc-γ1 in PDGF-Mediated Signal Transduction

1995 • 11 citations

The effect of phosphatidic acid on the proliferation of Swiss 3T3 cells

1993 • 11 citations

Inhibition of PDGF-Induced Phospholipase D but Not Phospholipase C Activation by Herbimycin A

1995 • 9 citations

Effects of phosphatidic acid on islet cell phosphoinositide hydrolysis, Ca2+, and adenylate cyclase

1989 • 9 citations

Function of Ca2+ influx in phospholipase D activation induced by prostaglandin F2α in osteoblast-like cells: Involvement of tyrosine kinase

1995 • 8 citations

Phospholipase D activation in PDGF-stimulated vascular smooth muscle cells

1993 • 4 citations