A Role for Phospholipase D in GLUT4 Glucose Transporter Translocation

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The insulin signaling system.

1994 • 1,733 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

1999 • 590 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

1999 • 417 citations

A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension

1999 • 414 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

Brefeldin A

1999 • 385 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Regulation of phospholipase D

1999 • 369 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Molecules in the ARF Orbit

1998 • 346 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

1997 • 290 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

1993 • 252 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

1998 • 249 citations

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

1998 • 206 citations

Measurement of Phospholipase D Activity

1997 • 202 citations

Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes

1998 • 200 citations

Synip

1999 • 183 citations

Phospholipase D and membrane traffic

1999 • 177 citations

Regulated Exocytosis in Chromaffin Cells

1998 • 165 citations

Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 151 citations

GLUT4Gene Regulation and Manipulation

1999 • 133 citations

Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain

1998 • 126 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity by Adenovirus-mediated Gene Transfer and Its Effect on Insulin Action

1998 • 119 citations

Phospholipid-binding protein domains

1998 • 116 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

ADP-ribosylation Factor 6 as a Target of Guanine Nucleotide Exchange Factor GRP1

1999 • 110 citations

Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes

1997 • 90 citations

Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles.

1999 • 86 citations

Regulation of phospholipase D by phosphorylation-dependent mechanisms

1999 • 86 citations

Pathways for phosphoinositide synthesis

1999 • 85 citations

Expression of phospholipase D isoforms in mammalian cells

1999 • 85 citations

ARF proteins mediate insulin-dependent activation of phospholipase D

1997 • 81 citations

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

1995 • 78 citations

Fcγ Receptor-Mediated Activation of Phospholipase D Regulates Macrophage Phagocytosis of IgG-Opsonized Particles

1999 • 74 citations

The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes

1996 • 68 citations

ADP-ribosylation Factor-1 Stimulates Formation of Nascent Secretory Vesicles from the trans-Golgi Network of Endocrine Cells

1996 • 68 citations

The Small Guanosine Triphosphate-Binding Protein Rab4 Is Involved in Insulin-Induced GLUT4 Translocation and Actin Filament Rearrangement in 3T3-L1 Cells*

1997 • 66 citations

A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1

1999 • 61 citations

Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes.

1988 • 58 citations

Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes

1999 • 55 citations

Stimulated Mitogen-activated Protein Kinase Is Necessary but Not Sufficient for the Mitogenic Response to Angiotensin II

1996 • 51 citations

ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles

1998 • 46 citations

Inositol phospholipids: Translocation, translocation, translocation …

1998 • 39 citations

Modular PH and C2 domains in membrane attachment and other functions

1999 • 33 citations

Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors

1999 • 20 citations

Untitled

1999 • 19 citations

Regulation of Early Endosome Fusion by Phospholipase D Activity

1997 • 12 citations