Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Receptor tyrosine kinase substrates: src homology domains and signal transduction

1992 • 156 citations

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.

1992 • 150 citations

Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

1996 • 149 citations

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.

1993 • 147 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

1995 • 143 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells

1996 • 118 citations

Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 Exoenzyme

1995 • 102 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Activation of Ras and Other Signaling Pathways by Receptor Tyrosine Kinases

1994 • 93 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein- and tyrosine kinase-based mechanisms

1993 • 78 citations

The identification and characterization of an epidermal growth factor-stimulated phosphorylation of a specific low molecular weight GTP-binding protein in a reconstituted phospholipid vesicle system.

1990 • 60 citations

ATP-induced potentiation of G-protein-dependent phospholipase D activity in a cell-free system from U937 promonocytic leukocytes.

1993 • 50 citations

Rac-dependent and -independent Pathways Mediate Growth Factor-induced Ca2+ Influx

1996 • 45 citations

Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH‐3T3 fibroblasts

1993 • 42 citations

A Small GTP-binding Protein, Rho, Associates with the Platelet-derived Growth Factor Type-β Receptor upon Ligand Binding

1995 • 27 citations

Phosphatidylcholine hydrolysis: a source of multiple lipid messenger molecules

1993 • 9 citations

GTPγS-Stimulated Phospholipase D Activation in Human Neutrophils Occurs by Protein Kinase C-Dependent and -Independent Pathways but Not via Tyrosine Kinases

1996 • 8 citations