Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.

1987 • 232 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species.

1984 • 173 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Induction of differentiation of cultured human and mouse myeloid leukemia cells by alkyl-lysophospholipids.

1981 • 101 citations

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1987 • 93 citations

Structural and chemical specificity of diradylglycerols for protein kinase C activation

1984 • 92 citations

1-O-hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells

1984 • 65 citations

Alkyl analogs of diacylglycerol as activators of protein kinase C

1987 • 61 citations

Disparate effects of activators of protein kinase C on HL-60 promyelocytic leukemia cell differentiation.

1987 • 60 citations

Phosphatidylcholine metabolism in endothelial cells: Evidence for phospholipase A and a novel Ca2+-independent phospholipase C

1987 • 58 citations

Pathways of arachidonic acid liberation in thrombin and calcium ionophore A23187-stimulated human endothelial cells: Respective roles of phospholipids and triacylglycerol and evidence for diacylglycerol generation from phosphatidylcholine

1987 • 56 citations

Synthesis of sulfur analogs of alkyl lysophospholipid and neoplastic cell growth inhibitory properties

1986 • 47 citations

The degradation of platelet‐activating factor and related lipids: Susceptibility to phospholipases C and D

1987 • 46 citations

Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain

1984 • 22 citations

Induction of myeloid differentiation of HL-60 cells with naphthalene sulfonamide calmodulin antagonists.

1986 • 14 citations