The cAMP-specific Phosphodiesterase PDE4D3 Is Regulated by Phosphatidic Acid Binding

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Molecular cloning: A laboratory manual

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

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1994 • 410 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

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1996 • 402 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Optical Isomers of Propranolol

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Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

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Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 297 citations

The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions

1998 • 292 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Bromoenol Lactone Inhibits Magnesium-dependent Phosphatidate Phosphohydrolase and Blocks Triacylglycerol Biosynthesis in Mouse P388D1 Macrophages

1996 • 218 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Coomassie brilliant blue staining of lipids on thin-layer plates

1984 • 211 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling

1996 • 189 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

ARF signaling: A potential role for phospholipase D in membrane traffic

1993 • 161 citations

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model

1998 • 160 citations

Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells

1995 • 145 citations

Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels

1998 • 138 citations

A role for phospholipase D in control of mitoqenesis

1994 • 137 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

UCR1 and UCR2 Domains Unique to the cAMP-specific Phosphodiesterase Family Form a Discrete Module via Electrostatic Interactions

2000 • 120 citations

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

1996 • 118 citations

Cloning and expression analysis of murine phospholipase D1

1997 • 115 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C.

1992 • 110 citations

Short Term Feedback Regulation of cAMP in FRTL-5 Thyroid Cells

2000 • 106 citations

Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells

1989 • 106 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Activation of the cAMP-specific Phosphodiesterase PDE4D3 by Phosphorylation

1999 • 91 citations

Phosphorylation-mediated Activation and Translocation of the Cyclic AMP-specific Phosphodiesterase PDE4D3 by Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinases

1999 • 87 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1994 • 82 citations

A Novel Phosphatidylserine-binding Peptide Motif Defined by an Anti-idiotypic Monoclonal Antibody

1995 • 71 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Selective Activation of Rolipram-Sensitive, cAMP-Specific Phosphodiesterase Isoforms by Phosphatidic Acid

1997 • 63 citations

Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase

1991 • 56 citations

ARF-regulated phospholipase D: a potential role in membrane traffic

1996 • 52 citations

Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents.

1993 • 48 citations

Glycerophosphoinositol 4-phosphate, a putative endogenous inhibitor of adenylylcyclase.

1993 • 35 citations

Involvement of Type 4 cAMP-Phosphodiesterase in the Myogenic Differentiation of L6 Cells

1999 • 34 citations

Phosphatidic acid stimulates the rolipram-sensitive cyclic nucleotide phosphodiesterase from rat thymocytes

1993 • 34 citations

Selective Stimulation of a CAMP‐Specific Phosphodiesterase (PDE4A5) Isoform by Phosphatidic Acid Molecular Species Endogenously Formed in Rat Thymocytes

1997 • 33 citations

Yrb1p Interaction with the Gsp1p C Terminus Blocks Mog1p Stimulation of GTP Release from Gsp1p

2000 • 25 citations

Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.

1992 • 25 citations

Triggering of a Phospholipase D Pathway Upon Mitogenic Stimulation of Human Peripheral Blood Mononuclear Cells Enriched with 12(S)‐hydroxyicosatetraenoic Acid

1995 • 20 citations

Regulation of PDE-4 cAMP phosphodiesterases by phosphatidic acid

1998 • 19 citations

Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells

1999 • 17 citations

Cyclic AMP responses are suppressed in mammalian cells expressing the yeast low Km cAMP-phosphodiesterase gene.

1990 • 13 citations

Agents that increase phosphatidic acid inhibit the LH-induced testosterone production

1994 • 11 citations

ADH resistance of LLC-PK1 cells caused by overexpression of cAMP-phosphodiesterase type-IV

1993 • 9 citations