Activation and activities of the p53 tumour suppressor protein

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Surfing the p53 network

2000 • 6,487 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

RING Finger Proteins

2000 • 1,216 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

1999 • 908 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

2000 • 877 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

p53

2000 • 785 citations

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

2000 • 781 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Role of NF-κB in p53-mediated programmed cell death

2000 • 730 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

The ARF/p53 pathway

2000 • 647 citations

SUMO-1 modification activates the transcriptional response of p53

1999 • 627 citations

MDMX: a novel p53-binding protein with some functional properties of MDM2.

1996 • 624 citations

GADD45 induction of a G ₂ /M cell cycle checkpoint

1999 • 607 citations

Functions of the MDM2 oncoprotein

1999 • 556 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

twist is a potential oncogene that inhibits apoptosis

1999 • 511 citations

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1

1999 • 507 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2

1999 • 479 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

The function of PML in p53-dependent apoptosis

2000 • 464 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

2000 • 416 citations

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

2000 • 415 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Regulation of p53 stability

1999 • 413 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

14-3-3 proteins: regulation of subcellular localization by molecular interference

2000 • 410 citations

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

2000 • 394 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Regulation of p53 activity in nuclear bodies by a specific PML isoform

2000 • 371 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

2000 • 367 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

2000 • 361 citations

Stress Signals Utilize Multiple Pathways To Stabilize p53

2000 • 355 citations

The MDM2 RING-finger domain is required to promote p53 nuclear export

2000 • 352 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

2001 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

JNK targets p53 ubiquitination and degradation in nonstressed cells

1998 • 339 citations

A role for p53 in base excision repair

2001 • 332 citations

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

2000 • 330 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

MDM2 interacts with MDMX through their RING finger domains

1999 • 319 citations

High mobility group protein-1 (HMG-1) is a unique activator of p53

1998 • 316 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

Genes involved in senescence and immortalization

2000 • 306 citations

Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability

1997 • 305 citations

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

1994 • 300 citations

The candidate tumour suppressor p33ING1cooperates with p53 in cell growth control

1998 • 294 citations

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

2000 • 285 citations

A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

1997 • 285 citations

Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

1999 • 282 citations

Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

2000 • 274 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

2000 • 257 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

The p53-deficient mouse: a model for basic and applied cancer studies

1996 • 256 citations

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

1999 • 255 citations

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

2000 • 252 citations

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

1997 • 249 citations

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.

1995 • 247 citations

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

1999 • 246 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

1998 • 242 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

2000 • 238 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Excess beta -catenin promotes accumulation of transcriptionally active p53

1999 • 236 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

2000 • 228 citations

Activation of p53 in cervical carcinoma cells by small molecules

2000 • 227 citations

Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress

2000 • 223 citations

P53 tumor suppressor gene therapy for cancer.

1998 • 220 citations

MdmX Protects p53 from Mdm2-Mediated Degradation

2000 • 212 citations

Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation

1998 • 210 citations

Mdm2 binds p73α without targeting degradation

1999 • 206 citations

Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase

2000 • 204 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

2000 • 197 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

p53 and human cancers

1994 • 192 citations

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

2000 • 188 citations

Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

1998 • 186 citations

Identification of a cryptic nucleolar-localization signal in MDM2

2000 • 186 citations

P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB

1999 • 184 citations

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

1999 • 184 citations

Ataxia‐telangiectasia, cancer and the pathobiology of the ATM gene

1999 • 182 citations

Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene

1997 • 172 citations

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

1998 • 170 citations

The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

1996 • 170 citations

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1994 • 168 citations

Involvement of p53 in cell differentiation and development

1997 • 163 citations

Proteolysis by Calpains: a Possible Contribution to Degradation of p53

1997 • 162 citations

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

1999 • 161 citations

Apoptosis: checkpoint at the mitochondrial frontier

1999 • 152 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb

1998 • 142 citations

The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal

1997 • 141 citations

p19 ^Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

1998 • 137 citations

Covalent and noncovalent modifiers of the p53 protein

1999 • 133 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

MDM2 and MDMX bind and stabilize the p53-related protein p73

1999 • 132 citations

Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max

1999 • 124 citations

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

2000 • 119 citations

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

2000 • 106 citations

The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes

1994 • 106 citations

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53

1999 • 104 citations

Analysis of the degradation function of Mdm2.

1999 • 104 citations

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

2001 • 102 citations

Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells.

1999 • 98 citations

Murine Double Minute (MDM2) Blocks p53-coactivator Interaction, a New Mechanism for Inhibition of p53-dependent Gene Expression

1999 • 96 citations

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

2000 • 93 citations

A Novel Cellular Protein (MTBP) Binds to MDM2 and Induces a G1 Arrest That Is Suppressed by MDM2

2000 • 92 citations

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

1998 • 89 citations

Apoptotic and Growth-Promoting Activity of E2F Modulated by MDM2

2000 • 88 citations

Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G₁ Arrest

1995 • 77 citations

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

2000 • 77 citations

p53 tumor suppressor gene therapy for cancer.

1999 • 77 citations

Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression

1999 • 76 citations

p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.

1998 • 73 citations

Cytoplasmically “Sequestered” Wild Type p53 Protein Is Resistant to Mdm2-mediated Degradation

1999 • 73 citations

p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53

2000 • 71 citations

Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition

1997 • 71 citations

Potential roles for p53 in nucleotide excision repair

1999 • 68 citations

Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.

2000 • 68 citations

One Mechanism for Cell Type-specific Regulation of thebax Promoter by the Tumor Suppressor p53 Is Dictated by the p53 Response Element

1999 • 63 citations

The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation

1997 • 62 citations

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

2000 • 61 citations

Adenovirus‐mediated Transfer of p53‐related Genes Induces Apoptosis of Human Cancer Cells

2000 • 60 citations

Influence of p53 tumor suppressor protein on bias of DNA repair and apoptotic response in human cells

1999 • 59 citations

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

1999 • 57 citations

Regulation of p53-Mediated Apoptosis and Cell Cycle Arrest by Steel Factor

1995 • 56 citations

Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015

2000 • 56 citations

Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes.

1996 • 55 citations

The Werner syndrome protein contributes to induction of p53 by DNA damage

2000 • 49 citations

MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins.

1999 • 47 citations

Unmasking of phosphorylation-sensitive epitopes on p53 and Mdm2 by a simple Western-phosphatase procedure

2000 • 40 citations

Identification of a CK2 phosphorylation site in mdm2

1999 • 39 citations

New insights into p53 regulation and gene therapy for cancer

2000 • 33 citations

UV but not gamma irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription.

2000 • 27 citations

p53-Independent Down-Regulation of Mdm2 in Human Cancer Cells Treated with Adriamycin

2000 • 16 citations

Clonal p53 mutation in primary cervical cancer: Association with human‐papillomavirus‐negative tumours

1992 • 8 citations

Cytoplasmically “sequestered” wild type p53 protein is resistant to Mdm2-mediated degradation.

2000 • 7 citations