The ARF/p53 pathway

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Exit from Mitosis Is Triggered by Tem1-Dependent Release of the Protein Phosphatase Cdc14 from Nucleolar RENT Complex

1999 • 720 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

1999 • 566 citations

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

1998 • 560 citations

P19 ^ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1999 • 543 citations

The INK4A/ARF locus and its two gene products

1999 • 532 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Tumor spectrum in ARF-deficient mice.

1999 • 339 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

1994 • 300 citations

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

1999 • 255 citations

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16 ^INK4a but not by the alternative reading frame protein p19 ^ARF

1997 • 220 citations

p19 ^Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

1998 • 137 citations

Modeling mutations in the G₁ arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a–ARF induces hyperploidy in cultured mouse astrocytes

1998 • 124 citations

Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.

1999 • 120 citations

Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm^−/− Mice

1998 • 101 citations

Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.

1997 • 83 citations