p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Signaling to p53

1998 • 636 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

P19 ^ARF stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1999 • 543 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

1993 • 250 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

1997 • 208 citations

The p53 response to ionising radiation in adult and developing murine tissues.

1996 • 206 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

1996 • 170 citations

Physical and functional interaction between wild-type p53 and mdm2 proteins.

1994 • 135 citations

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

1998 • 127 citations

The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ^ARF

1999 • 68 citations

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

1998 • 66 citations

Multiple Murine Double Minute Gene 2 (MDM2) Proteins Are Induced by Ultraviolet Light

1999 • 46 citations

Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation.

1998 • 32 citations

Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection.

1995 • 30 citations