MDM2 Suppresses p73 Function without Promoting p73 Degradation

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

1998 • 2,061 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1998 • 535 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

p53 in growth control and neoplasia

1996 • 488 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

1996 • 354 citations

Big Brother

1997 • 353 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

A novel protein with strong homology to the tumor suppressor p53

1997 • 282 citations

Repression of p53-mediated transcription by MDM2: a dual mechanism

1997 • 272 citations

Mdm2: keeping p53 under control

1997 • 267 citations

Mapping of the p53 and mdm-2 Interaction Domains

1993 • 241 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Mdm-2: “big brother” of p53

1997 • 175 citations

The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain

1996 • 170 citations

Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1998 • 161 citations

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

1998 • 158 citations

Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.

1998 • 131 citations

A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein

1997 • 87 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.

1998 • 73 citations

p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?

1997 • 58 citations

Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53

1998 • 28 citations

MDM2 function

1998 • 19 citations

A Conserved Region of Unknown Function Participates in the Recognition of E2F Family Members by the Adenovirus E4 ORF 6/7 Protein

1996 • 16 citations

The regulation of p53-mediated transcription and the roles of hTAFII31 and mdm-2.

1994 • 9 citations

IMMUNOAFFINITY PURIFICATION

1994 • 8 citations