p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

1998 • 432 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

2000 • 397 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

p53 and apoptosis

1998 • 282 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response

1996 • 260 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

1997 • 249 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Wild-type p53 negatively regulates the expression of a microtubule-associated protein.

1996 • 223 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells.

1993 • 213 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

2000 • 168 citations

Regulation of ES cell differentiation by functional and conformational modulation of p53

1997 • 156 citations

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1999 • 134 citations

Impaired Intracellular Trafficking Is a Common Disease Mechanism ofPMP22Point Mutations in Peripheral Neuropathies

1999 • 121 citations

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

1999 • 111 citations

Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex.

1996 • 87 citations

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1999 • 73 citations

Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53.

1995 • 66 citations

p53 transactivation domain mutant Q22, S23 is impaired for repression of promoters and mediation of apoptosis.

1996 • 26 citations