Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

The p53 Network

1998 • 731 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Polarization of the fluorescence of macromolecules. 1. Theory and experimental method

1952 • 673 citations

Signaling to p53

1998 • 636 citations

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 • 555 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Phosphate groups as substrate determinants for casein kinase I action.

1990 • 331 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

1994 • 234 citations

Fluorescence polarization analysis of protein-DNA and protein-protein interactions.

1996 • 220 citations

Multisite Phosphorylation and the Integration of Stress Signals at p53

1998 • 185 citations

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1999 • 182 citations

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

1997 • 167 citations

Isolation and Characterization of Human Casein Kinase I∊ (CKI), a Novel Member of the CKI Gene Family

1995 • 166 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

Fluorescence anisotropy: Rapid, quantitative assay for protein-DNA and protein-protein interaction

1996 • 151 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1999 • 138 citations

Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.

1993 • 135 citations

Phosphorylation of p53: a Novel Pathway for p53 Inactivation in Human T-Cell Lymphotropic Virus Type 1-Transformed Cells

1998 • 134 citations

Three-dimensional Structure of Mammalian Casein Kinase I: Molecular Basis for Phosphate Recognition

1996 • 125 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae

1997 • 105 citations

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts.

1996 • 76 citations

Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues

1995 • 51 citations

The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth

1997 • 6 citations