MDM2 interacts with MDMX through their RING finger domains

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1998 • 688 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

MDMX: a novel p53-binding protein with some functional properties of MDM2.

1996 • 624 citations

p53 in growth control and neoplasia

1996 • 488 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

1996 • 272 citations

p53-Independent Role of MDM2 in TGF-β1 Resistance

1998 • 195 citations

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

1998 • 153 citations

Isolation and Identification of the Human Homolog of a New p53-Binding Protein, Mdmx

1997 • 151 citations

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

1997 • 129 citations

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

1997 • 125 citations

Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases

1997 • 103 citations