RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

Antibodies, a laboratory manual

1989 • 12,929 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Signaling to p53

1998 • 636 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Control of pRB phosphorylation

1998 • 389 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

High level expression of p27 ^kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 ^kip1 and degree of malignancy in human breast and colorectal cancers

1997 • 364 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

Repression of p53-mediated transcription by MDM2: a dual mechanism

1997 • 272 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

1996 • 234 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors.

1997 • 222 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

Altered Retinoblastoma Protein Expression and Prognosis in Early-Stage Non-Small-Cell Lung Carcinoma

1994 • 130 citations

E2F-1-Induced p53-independent apoptosis in transgenic mice

1998 • 126 citations

Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner

1995 • 109 citations

Deletion of RBExons 24 and 25 Causes Low-Penetrance Retinoblastoma

1997 • 99 citations

Domains A and B in the Rb Pocket Interact To Form a Transcriptional Repressor Motif

1996 • 98 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

1996 • 89 citations

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F

1998 • 79 citations

The Rb Family Contains a Conserved Cyclin-Dependent-Kinase-Regulated Transcriptional Repressor Motif

1996 • 67 citations

Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation.

1996 • 66 citations

Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis.

1997 • 58 citations

p53 phosphorylation mutants retain transcription activity.

1995 • 54 citations

Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: potential synergistic effects on prognosis.

1996 • 51 citations