Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 • 795 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.

1994 • 355 citations

Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes.

1991 • 313 citations

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

1993 • 250 citations

Prospective Study of a Family Cancer Syndrome

1982 • 230 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.

1994 • 133 citations

Sensitive determination of pyrimidine dimers in DNA of UV-irradiated mammalian cells Introduction of T4 endonuclease V into frozen and thawed cells

1981 • 124 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

Binding of Basal Transcription Factor TFIIH to the Acidic Activation Domains of VP16 and p53

1994 • 112 citations

Repair and Transcription: Collision or collusion?

1994 • 97 citations

Xeroderma Pigmentosum Complementation Group C Cells Remove Pyrimidine Dimers Selectively from the Transcribed Strand of Active Genes

1991 • 92 citations

Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene.

1993 • 57 citations

Genes controlling nucleotide excision repair in eukaryotic cells

1993 • 44 citations

Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells

1995 • 42 citations

Preferential repair of ultraviolet light‐induced dna damage in the transcribed strand of the human p53 gene

1994 • 39 citations

Increased UV Resistance of a Xeroderma Pigmentosum Revertant Cell Line is Correlated with Selective Repair of the Transcribed Strand of an Expressed Gene

1993 • 21 citations