SUMO-1 modification activates the transcriptional response of p53

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p

1997 • 488 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1

1999 • 353 citations

Ubch9 conjugates SUMO but not ubiquitin

1997 • 349 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Evidence for Covalent Modification of the Nuclear Dot–associated Proteins PML and Sp100 by PIC1/SUMO-1

1997 • 329 citations

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

1997 • 315 citations

SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation

1999 • 305 citations

The p53-deficient mouse: a model for basic and applied cancer studies

1996 • 256 citations

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

1999 • 255 citations

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

1994 • 234 citations

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

1999 • 232 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

UBL1, a Human Ubiquitin-like Protein Associating with Human RAD51/RAD52 Proteins

1996 • 222 citations

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme

1998 • 210 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2

1998 • 193 citations

RanBP2 associates with Ubc9p and a modified form of RanGAP1

1997 • 190 citations

Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-like Molecule

1997 • 173 citations

Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex

1999 • 172 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo.

1996 • 120 citations

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

1995 • 117 citations

Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

1995 • 71 citations

Awakening angels

1998 • 54 citations

Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6.

1995 • 45 citations

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability 1 1Edited by J. Karn

1998 • 36 citations

The carboxy-terminus of IκBα determines susceptibility to degradation by the catalytic core of the proteasome

1997 • 36 citations

Deleted Work

1955 • 0 citations